Detection is unsophisticated and currently inadequate; the guidance that 3 months is enough is not good enough and draws parallels with hypertension detection. Current evidence on intervention and effectiveness seems very light. I have asked everyone (including this journal) to provide me with a NNT for a patient with CKD III who need detecting and intervening with to prevent either a cardiovas...

C-reactive protein (CRP) is a member of the pentraxin family of proteins, which are characterised by a cyclic pentameric structure and radial symmetry. The five identical 24-kDa protomers consist of 206 amino acids, and are noncovalently linked. CRP binds to a range of substances such as phosphocholine, fibronectin, chromatin, histones, and ribonucleoprotein in a calcium-dependent manner. It is...

Calciphylaxis is a relatively rare disorder associated with calcification of smalland medium-sized blood vessels, progressive ischemic skin necrosis, and ulcerations. This situation is a potentially life-threatening condition seen in patients with endstage renal disease (ESRD). A 64-year-old man with ESRD on dialysis for 6 years was admitted to our clinic with severe pain and partial necrosis o...

A 59-year-old Chinese patient had a history of endstage renal disease secondary to glomerulonephritis and underwent peritoneal dialysis. Nine years after initiation of dialysis, he developed an enlarging ‘tumour’ over his right wrist in the absence of antecedent trauma. Within 1 month of presentation, he was unable to use chopsticks because of the painful mass. At that time, his serum calcium a...

background: cardiovascular mortality and morbidity are high in chronic renal failure (crf) patients. increased dispersion of qt intervals is known to predispose to ventricular arrhythmias and sudden cardiac death. this study was conducted to assess the effect of hemodialysis (hd) on corrected qt (qtc) intervals and their dispersions (qtd) in chronic hemodialyzed patients. methods: fifty-eight p...

Tekdos Demircioğlu et al. found that the prevalence of RLS among patients undergoing HD was high (41%).[1] In addition, a review article noted the prevalence of “uremic RLS” was approximately 30% in endstage renal disease (ESRD) patients.[2] However, its prevalence in this group ranged between 6.6% and 80% in various reports.[3–5] Based on the International RLS Study Group (IRLSSG) criteria, an...

Anemia is one of the leading causes of morbidity in chronic renal failure.1 Chronic kidney disease (CKD) associated anemia is largely due to reduced erythropoietin (EPO) release and, to a lesser degree, to shortened red cell survival.2 To overcome EPO deficiency in this population, the development and administration of erythropoiesis-stimulating agents (ESAs) such as recombinant human EPO and d...

background this retrospective study aimed to determine the epidemiologic characteristics and risk factors of chronic kidney diseases (ckd) in patients < 18 years old at a single referral center. materials and methods in a hospital-based case control study, 66 ckd patients less than 18 years old were compared to 81 control patients (also under 18) without ckd. a patient was defined as a ckd case...

study of a family with autosomal dominant polycystic kidney diseases (adpkd) in five generations, including 96 healthy and 47 affected individuals, has been carried out in tehran. investigation on individuals, including final diagnoses by clinical findings, sonography, radiography and laboratory results, have lead to the completion of genealogical chart of the family. the affected individuals h...

results there are many pitfalls in diagnosis of utis both with urinalysis and culture methods and also in evaluating the risk factors and causes of utis. conclusions this paper reviews and discusses the common pitfalls in diagnosis and evaluation of utis in children. context urinary tract infections (utis) are among the most common infections in children that affect up to 3% of boys and 8% of g...