BACKGROUND Impaired microcirculation during endotoxemia correlates with a disturbed arginine-nitric oxide (NO) metabolism and is associated with deteriorating organ function. Improving the organ perfusion in endotoxemia, as often seen in patients with severe infection or systemic inflammatory response syndrome (SIRS) is, therefore, an important therapeutic target. We hypothesized that supplemen...

One of the most commonly encountered life-threatening conditions in horses with gastrointestinal disease is endotoxemia. The results of studies of horses presented with abdominal pain (colic) to university clinics in various parts of the world indicate that gram-negative bacterial endotoxins commonly are detected in circulation. Although much of the focus of research on endotoxemia in horses ha...

Objective(s):Lipopolysaccharide (LPS)-induced endotoxemia is known to cause male infertility. This study was designed to explore the effects of bacterial LPS on histomorphometric changes of mice testicular tissues.    Materials and Methods: In experiment 1, a pilot dose responsive study was performed with mice that were divided into five groups, receiving 36000, 18000, 9000, and 6750 µg/kg body...

When endotoxins are given intravenously the granulocytes leave the active stream of the circulation and congregate chiefly in the capillaries of the lung, spleen and liver. The same phenomenon can be expected to occur in hemorrhagic shock because experimental evidence suggests that the loss of the antibacterial defenses in shock results in the development of an endotoxemia (1). This paper prese...

This article contains animal experimental data associated with the research article entitled "GTS-21 reduces microvascular permeability during experimental endotoxemia" (Schmidt et al., 2017) [1] (supplementary datasets of baseline intravital microscopic measurements, baseline TNF-α levels and vital parameters of the evaluated experimental groups are provided). Beneficial anti-inflammatory effe...

In the past three decades, a considerable amount of information has arisen about the involvement of endotoxins in horses with gastrointestinal diseases. The purpose of this paper is to provide a succinct review of the pathogenesis of endotoxemia and its treatment. This will be accomplished by first defining endotoxins, identifying how these toxins interact with specific plasma proteins and cell...

INTRODUCTION Two recent, independent, studies conducted novel metabolomics analyses relevant to human sepsis progression; one was a human model of endotoxin (lipopolysaccharide (LPS)) challenge (experimental endotoxemia) and the other was community acquired pneumonia and sepsis outcome diagnostic study (CAPSOD). The purpose of the present study was to assess the concordance of metabolic respons...

The high prevalence of sepsis in intensive care units and emergency rooms, along with the high lethality of the sepsis cases makes the study of pathophysiology of sepsis critically important. As a preclinical model, endotoxemia is an important tool to study the pathophysiology of sepsis and septic shock. In this review, we discussed aspects of endotoxemia as an experimental model in sepsis rese...