BACKGROUND Matrix metalloproteinases (MMPs) and their inhibitors are key-players in extracellular matrix and basement membrane degradation, and are involved in both physiological and malignant processes. The aim of this study was to examine MMP-2, -7 and -9 and TIMP-1 and -2 expression in normal, hyperplastic and malignant endometrium, and their relation to clinical and histological prognostic ...

During embryo implantation in pigs, the uterine endometrium undergoes dramatic morphological and functional changes accompanied with dynamic gene expression. Since the greatest amount of embryonic losses occur during this period, it is essential to understand the expression and function of genes in the uterine endometrium. Although many reports have studied gene expression in the uterine endome...

background: there is a fundamental correlation between follicles and endometrium in intracytoplasmic sperm injection (icsi) cycles. objective: to assess the relation between perifollicular perfusion and sub endometrial parameters in doppler ultrasonography and outcome of in icsi cycles. materials and methods: in this prospective deh1ive pilot study 10 patients were enrolled. strict inclusion cr...

background: acceptance of uterus and reaction between endometrium and embryo has an important role for implantation. muc1 an integral membrane mucin is expressed on the apical surface of uterine epithelial cells and could have effects on its receptivity. objective: the aim of this study was to evaluate the changes in muc1 expression of gravid mouse endometrium with and without hyperstimulation ...

To the editor: Hereditary portion and genetic status are very important to work out strategies for cancer prevention and early detection in gynecologic cancers. Familial history of related cancers within the second degree relatives are approximately 10% and 20% in endometrial cancer and ovarian cancer, respectively [1,2]. The proportion of genetic background and germline mutation in Korean wome...

Endometriosis is considered as a benign aseptic inflammatory disease, characterised by the presence of ectopic endometrium-like tissue. Its symptoms (mostly pain and infertility) are reported as constant stressors. Corticotropin releasing hormone (CRH) and urocortin (UCN) are neuropeptides, strongly related to stress and inflammation. The effects of CRH and UCN are mediated through CRHR1 and CR...

Infertility is one of the most prevalent chronic health disorders involving young adults. defined as failure to establish a clinical pregnancy after 12 months regular and unprotected sexual intercourse. Endometrium important factors for successful pregnancy. Endometrial thickness marker endometrial receptivity prognostic factor A thin endometrium generally less than 7 mm. Thin adversely affect ...

AIM To study the transcriptome profiles in the blood of recurrent implantation failure (RIF), recurrent miscarriage (RM) and fertile women during the window of implantation, and further analysis the correlation of transcriptome profiles between blood and endometrium. METHODS This is an observational prospective study. In total 9 subjects were recruited, 3 RIF, 3 RM, and 3 controls. Paired sam...

The endometrium is one of the most dynamic structures in the human body characterised hy a complete life cycle within a short span of time. Although there can be no doubt about the role of estrogen in promoting endometrial growth and progesterone in influencing the differentiation, yet little is known of the mechanisms by which such changes are accomplished. Behind the constantly changing struc...

Placental protein 14 (PP14) is a glycoprotein which is secreted by secretory phase endometrium and decidua in women. Despite the suggestion that PP14 is involved in the process of endometrial maturation for blastocyst implantation, our understanding in this regard is poor. In the present study, the concentrations and distribution patterns of immunodetectable PP14 in the endometrium during proli...