نتایج جستجو برای: endochondral bone

تعداد نتایج: 305621  

Journal: :Development 1989
S Moskalewski J Malejczyk

Isolated syngeneic epiphyseal chondrocytes transplanted into a muscle formed cartilage in which matrix resorption and endochondral ossification began at the end of the second week after transplantation. After 56 days cartilage was converted into an ossicle. In 7-day-old intrarenal transplants, epiphyseal chondrocytes formed nodules of cartilage. In 10-day-old transplants, islands of bone appear...

2010
Yan Chen David Silkstone Yasha Amani Benjamin A. Alman

Fracture healing is a complex regenerative process. Although the histology and general mechanism of repair process are already clear and well established, much remains to be understood about the process of bone healing. The source of the cells that initiate fracture repair are unclear. It is thoght that fracture repair is initiated by mesenchymal progenitor cells (MPCs) which undergo differenti...

ژورنال: دانشور پزشکی 2010

Background and Objective: One of the major concerns of surgeons and patients is repairing of bone loss due to various factors. Many materials have been made to improve the quantity and quality of bone loss repair. The aim of this research was radiographic evaluation of healing process of human bone loss created after implantation of HECBMG (Human Endochondral Bone Matrix Gelatin) and DBM (Demin...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2002
John Street Min Bao Leo deGuzman Stuart Bunting Franklin V Peale Napoleone Ferrara Hope Steinmetz John Hoeffel Jeffrey L Cleland Ann Daugherty Nicholas van Bruggen H Paul Redmond Richard A D Carano Ellen H Filvaroff

Several growth factors are expressed in distinct temporal and spatial patterns during fracture repair. Of these, vascular endothelial growth factor, VEGF, is of particular interest because of its ability to induce neovascularization (angiogenesis). To determine whether VEGF is required for bone repair, we inhibited VEGF activity during secondary bone healing via a cartilage intermediate (endoch...

Journal: :Mechanisms of Development 2002
Christa Maes Peter Carmeliet Karen Moermans Ingrid Stockmans Nico Smets Désiré Collen Roger Bouillon Geert Carmeliet

Vascular endothelial growth factor (VEGF)-mediated angiogenesis is an important part of bone formation. To clarify the role of VEGF isoforms in endochondral bone formation, we examined long bone development in mice expressing exclusively the VEGF120 isoform (VEGF120/120 mice). Neonatal VEGF120/120 long bones showed a completely disturbed vascular pattern, concomitant with a 35% decrease in trab...

Journal: :Clinical oral implants research 2014
Alberto Monje Florencio Monje Pablo Galindo-Moreno Jesus Montanero-Fernandez Fernando Suarez Hom-Lay Wang

PURPOSE The main purpose of the present clinical study was to compare architectural metric parameters using micro-computed tomography (μ-CT) between sites grafted with blocks harvested from the intramembranous origin calvarium and endochondral origin iliac crest for horizontal bone augmentation in the maxilla. The second aim was to compare primary stability of implants placed in both types of b...

Journal: :Journal of dental research 2005
G H Tang A B M Rabie

Runx2 is a transcription factor prerequisite for chondrocyte maturation and osteoblast differentiation. We tested the hypothesis that Runx2 is responsible for signaling chondrocyte maturation and endochondral ossification in the condyle during mandibular advancement. Fifty 35-day-old Sprague-Dawley rats were fitted with functional appliances for 3, 7, 14, 21, and 30 days. Experimental animals w...

Journal: :PloS one 2016
Anna E Rapp Ronny Bindl Stefan Recknagel Annika Erbacher Ingo Müller Hubert Schrezenmeier Christian Ehrnthaller Florian Gebhard Anita Ignatius

Following bone fracture, the repair process starts with an inflammatory reaction at the fracture site. Fracture healing is disturbed when the initial inflammation is increased or prolonged, whereby, a balanced inflammatory response is anticipated to be crucial for fracture healing, because it may induce down-stream responses leading to tissue repair. However, the impact of the immune response o...

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