Cannabis use has often been associated with various forms of psychosis. Today it is well established that everyone produces marijuana-like compounds known as endocannabinoids. The endocannabinoid system is a homeostatic regulator of all body systems including the nervous system. As a result, imbalances in the endocannabinoid system have been considered as possible causes of various forms of men...

2 3 Endocannabinoids mediate tachykinin induced effects in the lamprey locomotor 4 network 5 6 7 8 9 10 11 Carolina Thörn Pérez, Russell H. Hill, Abdeljabbar El Manira, Sten Grillner 12 Nobel Institute for Neurophysiology 13 Department of Neuroscience, Karolinska Institutet, 14 SE17177 Stockholm, Sweden 15 16 Running head: Endocannabinoids mediate tachykinin effects 17 18 19 20 21 Corresponding...

# Department of Biomedical Sciences, University of Teramo, 64100 Teramo, Italy, § L’Oréal Research and Innovation, Clichy, France, ¥ Department of Experimental Medicine and Biochemical Sciences, University of Rome “Tor Vergata”, 00133 Rome, Italy, & Center for Integrated Research (CIR)/University Campus Biomedico di Roma, 00128 Rome, Italy $ European Center for Brain Research (CERC)/Santa Lucia...

Endocannabinoids are lipid mediators of the same cannabinoid (CB) receptors that mediate the effects of marijuana. The endocannabinoid system (ECS) consists of CB receptors, endocannabinoids, and the enzymes involved in their biosynthesis and degradation, and it is present in both brain and peripheral tissues, including the liver. The hepatic ECS is activated in various liver diseases and contr...

Cannabis has been used medicinally for centuries to treat a variety of disorders, including those associated with the gastrointestinal tract. The discovery of our bodies' own "cannabis-like molecules" and associated receptors and metabolic machinery - collectively called the endocannabinoid system - enabled investigations into the physiological relevance for the system, and provided the field w...

The endocannabinoids anandamide and 2-arachydonoylglycerol (2-AG) are lipids naturally derived from membrane precursors which bind cannabinoid receptors (CB1, CB2). This endocannabinoid system is disturbed in schizophrenia. Indeed, there seems to be an association between schizophrenia and polymorphisms of the CB1 receptor gene. Moreover, CB1 receptors are found in higher density in the prefron...

The endogenous cannabinoid system-named for the plant that led to its discovery-is one of the most important physiologic systems involved in establishing and maintaining human health. Endocannabinoids and their receptors are found throughout the body: in the brain, organs, connective tissues, glands, and immune cells. With its complex actions in our immune system, nervous system, and virtually ...