Faults in computer networks may result in millions of dollars in cost. Faults in a network need to be localized and repaired to keep the health of the network. Fault management systems are used to keep today’s complex networks running without significant cost, either by using active techniques or passive techniques. In this paper, we propose a novel approach based on imperialist competitive alg...

Previous work suggested that phosphorylation of DNA-PKcs at several serine/threonine (S/T) residues at positions 2609-2647 promotes DNA-PK-dependent end joining. In an attempt to clarify the role of such phosphorylation, end joining was examined in extracts of DNA-PKcs-deficient M059J cells. Joining of ends requiring gap filling prior to ligation was completely dependent on complementation of t...

We present a method for detecting common human actions in video, common to athletics and surveillance, using intuitive sketches and motion cues. The framework presented in this paper is an automated end-to-end system which (1) interprets the sketch input, (2) generates a query video based on motion cues, and (3) incorporates a new contentbased action descriptor for matching. We apply our method...

Recent data indicate that loss of the protective telomeric capping function leads to active degradation of the telomeric G-strand overhang and DNA ligase IV-mediated non-homologous end joining. These molecular events may contribute to genomic instability early in tumorigenesis.

DNA-dependent protein kinase (DNA-PK) is an essential component of the nonhomologous end joining pathway (NHEJ), responsible for the repair of DNA double-strand breaks. Ku binds a DSB and recruits the catalytic subunit, DNA-PKcs, where it is activated once the kinase is bound to the DSB. The precise mechanism by which DNA activates DNA-PK remains unknown. We have investigated the effect of DNA ...

Among the many proteins used to repair DNA double-strand breaks by nonhomologous end joining (NHEJ) are two related family X DNA polymerases, Pol λ and Pol µ. Which of these two polymerases is preferentially used for filling DNA gaps during NHEJ partly depends on sequence complementarity at the break, with Pol λ and Pol µ repairing complementary and noncomplementary ends, respectively. To bette...

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