Controlled release systems can modify the rate of drugs and direct them to specific sites action, making more effective and/or reducing adverse effects. The objective this study was investigated, poly(β-hydroxybutyrate) (PHB) poly(ε-caprolactone) (PCL) nanospheres improve delivery Simvastatin (SIM). Nanospheres were prepared by emulsion/evaporation technique solvent, varying amount SIM added. q...

Nanoparticles of CoGdxFe2 ? xO4 (x = 0%, 25%, 50%) synthesized via sol–gel auto combustion technique and encapsulated within a polymer (Eudragit E100) shell containing curcumin by single emulsion solvent evaporation were formulated in this study. Testing nanoparticles was carried out using different characterization techniques, to investigate composition, crystallinity, size, morphology, surfac...

Polymethylmethacrylate (PMMA) coated microcapsules of diclofenac sodium (DFS) were prepared by a modified water-in-oil-in-water (W1/O/W2) emulsion solvent evaporation method using sodium alginate (SAL) as a matrix material in the internal aqueous phase (W1). Their performance with respect to controlled release of the drug in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) wer...

The classical utilized double emulsion solvent diffusion technique for encapsulating water soluble Mitomycin C (MMC) in PLA nanoparticles suffers from low encapsulation efficiency because of the drug rapid partitioning to the external aqueous phase. In this paper, MMC loaded PLA nanoparticles were prepared by a new single emulsion solvent evaporation method, in which soybean phosphatidylcholine...

The objective of the current investigation is to reduce dosing frequency and improve patient compliance by designing and systematically evaluating sustained release microspheres of Glipizide. An anti-diabetic drug, Glipizide, is delivered through the microparticulate system using ethyl cellulose as the controlled release polymer. Microspheres were developed by the emulsion solvent diffusion-eva...

The present investigation involves formulation and evaluation of microspheres with Repaglinide as model drug for prolongation of drug release time. An attempt was made to prepare microspheres of Repaglinide by Quasi emulsion solvent diffusion technique, with a view to deliver the drug at sustained or controlled manner in gastrointestinal tract and consequently into systemic circulation. The mic...

The objective of the current investigation is to reduce dosing frequency and improve patient compliance by designing and systematically evaluating sustained release microspheres enriched gel of econazole nitrate. An antifungal agent, Econazole nitrate, is delivered through the microparticulate system using ethyl cellulose as the controlled release polymer. Microspheres were developed by the emu...

The aim of this study was to prepare biodegradable sustained release magnetite microspheres sized between 1 to 2 microm. The microspheres with or without magnetic materials were prepared by a W/O/W double emulsion solvent evaporation technique using poly(lactide-co-glycolide) (PLGA) as the biodegradable matrix forming polymer. Effects of manufacturing and formulation variables on particle size ...