A new formulation method was developed for preparing poly(D,L-lactic-co-glycolic acid) (PLGA) nanoparticles loaded with recombinant human granulocyte colony-stimulating factor (rhG-CSF). Lyophilized rhG-CSF powder and PLGA polymer were directly co-dissolved in a single organic phase, and the resulting solution was dispersed into an aqueous solution. PLGA nanoparticles encapsulating rhG-CSF were...

Dichloromethane (DCM) and acetonitrile (ACN) are the most commonly used solvents for polylactic acid (PLA) or poly(lactic-co-glycolic acid) (PLGA). In order to select a suitable solvent system for the preparation of PLGA microspheres containing tumor necrosis factor-alpha (TNF-a), the stability of TNF-a when mixed with DCM and ACN under various phase conditions was investigated. When the TNF-a ...

Objective: The objective of the present study was to compare release effect Luliconazole from different polymeric (Hydrophilic and Hydrophobic) microsponges prepared using varying concentrations. best microsponge selected incorporated into gel (Natural synthetic) drug is determined compared with marketed formulation.
 Methods: Polymers such as EC, HPMC, Eudragit RSPO PVA emulsifier, solven...

The aim of this study was to measure permeation of the herbicide dichlobenil in Casoron 4G through disposable and chemically protective nitrile gloves using an American Society for Testing and Materials-type permeation cell and a closed-loop system employing two different solvents (hexane and water) and two different challenge situations (aqueous emulsion and solid formulation). Capillary gas c...

Controlled release systems can modify the rate of drugs and direct them to specific sites action, making more effective and/or reducing adverse effects. The objective this study was investigated, poly(β-hydroxybutyrate) (PHB) poly(ε-caprolactone) (PCL) nanospheres improve delivery Simvastatin (SIM). Nanospheres were prepared by emulsion/evaporation technique solvent, varying amount SIM added. q...

background microencapsulation is a useful method to prolong a drug release from dosage forms and to reduce its adverse effect (1) among various available methods. the microencapsulation of hydrophilic active ingredients requires the use of a polar dispersing phase such as a mineral oil. acetone/paraffin systems are conventionally used. objectives the current study aimed to investigate two diffe...

A microfluidic approach is reported for the high-throughput, continuous production of giant unilamellar vesicles (GUVs) using water-in-oil-in-water double emulsion drops as templates. Importantly, these emulsion drops have ultrathin shells; this minimizes the amount of residual solvent that remains trapped within the GUV membrane, overcoming a major limitation of typical microfluidic approaches...

a box-behnken design with three replicates was used for preparation and evaluation of eudragit vancomycin (vcm) nanoparticles prepared by double emulsion. the purpose of this work was to optimize vcm nanoparticles to improve the physicochemical properties. nanoparticles were formed by using w1/o/w2 double-emulsion solvent evaporation method using eudragit rs as a retardant material. full factor...