Limb bud (LB) and central nerve system (CNS) cells were prepared from 12.5 day old pregnant female Crj:CD (SD) rats and treated with olaquindox and vitamin A. Cytotoxicity and inhibition on differentiation were measured in each cell. Three doses of olaquindox (4, 21 and 100 mgkg) , and 0.2 and 75 mg/kg of vitamin A were administered to pregnant rat for 11 days from 6(th) to 16(th) of pregnancy....

This study was designed to investigate the possible developmental teratogenicity of norfloxacin in rats. Forty pregnant female rats were divided into four equal groups. Group A received norfloxacin in a dose of 500 mg/kg·b·wt/day orally from 6th to 15th day of gestation. Groups B and C received 1000 and 2000 mg/kg·b·wt/day orally for the same period, respectively; Group D behaved as control and...

Ribavirin (1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide) is a water-soluble, guanosine nucleoside analog that mimics other purines, including inosine and adenosine. The current study was designed to assess the embryotoxic effect of ribavirin investigate its teratogenic on placental fetal liver tissues. In this study, 18 pregnant Wistar rats (165–185 g) 11–13 weeks old were orally administra...

Abstract Niedenzuella (Tetrapterys) multiglandulosa, a vine plant found in Brazil, has been correlated to outbreaks of poisoning cattle and buffaloes, generating economic losses related the death due heart failure, miscarriage, abortion, stillbirth, neonatal mortality. The aim this study was examine embryotoxic potential aqueous extract on vitro bovine embryos. In performed five replicates embr...

Objective(s): In veterinary medicine, zeolites are used as toxin binder in animal feed, ammonia purification of aquatic pools, animal smell and moisture control. This study investigated on the risk assessment of nano zeolite on development of embryonic chicken models, anomalies, tetratogenic and embryotoxic effects. Methods: Eggs (120 = n) were accidentally di...