Infection with Leishmania donovani is associated with IL-10 as well as with GM-CSF. Immune complexes (IC) exert important functions by stimulation of monocytes/macrophage-mediated production of pro- and anti-inflammatory cytokines in rheumatic diseases. In this investigation, we have explored IC-induced cytokine production during Leishmania infection. Sera from 43 patients with visceral leishma...

Liver cancer has become one of the major types of cancer with high mortality and liver cancer is not responsive to the current cytotoxic agents used in chemotherapy. The purpose of this study was to examine the in vitro cytotoxicity of goniothalamin on human hepatoblastoma HepG2 cells and normal liver Chang cells. The cytotoxicity of goniothalamin against HepG2 and liver Chang cell was tested u...

Due to our interest in the chemical space of organic dyes identify potential small-molecule inhibitors (SMIs) for protein-protein interactions (PPIs), we initiated a screen such compounds assess their inhibitory activity against interaction between SARS-CoV-2 spike protein and its cognate receptor ACE2, which is first critical step initiating viral attachment entry this coronavirus responsible ...

In the legend for Figure 4, there is a misspelling. The correct spelling is: 50 mm. The authors have provided a corrected version here. Figure 5 is incorrect. Figure panel 5H was an inadvertent duplication of the figure panel 5G. Figures 5G and H show ELISA quantifications of extra(EC) and intracellular (IC) S1P levels in 3T3 cells (G) and cerebellar granule neurons (H) before and after 30 and ...