In this paper, we illustrate how advanced computational modelling and simulation can be used to investigate drug-induced effects on cardiac electrophysiology and on specific biomarkers of pro-arrhythmic risk. To do so, we first perform a thorough literature review of proposed arrhythmic risk biomarkers from the ionic to the electrocardiogram levels. The review highlights the variety of proposed...

Systems biology is currently making a bid to show that it is able to make an important contribution to personalised or precision medicine. In order to do so, systems biologists need to find a way of tackling the pervasive variability of biological systems that is manifested in the medical domain as inter-subject variability. This need is simultaneously social and epistemic: social as systems bi...

We study, by means of the periodic unfolding technique, homogenization a modified bidomain model, which describes propagation action potential in cardiac electrophysiology. Such allowing presence pathological zones heart, involves various geometries and non-standard transmission conditions on interface between healthy damaged part muscle.

CARDIAC ELECTROPHYSIOLOGY CLINICS www.cardiacEP.theclinics.com Consulting Editors RANJAN K. THAKUR ANDREA NATALE June 2021 • Volume 13 Number 2

CARDIAC ELECTROPHYSIOLOGY CLINICS www.cardiacEP.theclinics.com Consulting Editors RANJAN K. THAKUR ANDREA NATALE November 2021 • Volume 13 Number 4

Recently, significant achievements have beenmade in cardiac electrophysiology research, including Ca regulatory pathways, membrane ion channel-related intracellular signaling, and electrical remodeling in cardiomyopathies. The rapid progress in the basic research has led to applications of numerous new methods and strategies to clinical diagnoses and treatments. The efficacy of antiarrhythmic p...