One third of the burden of all the diseases in Europe is due to problems caused by diseases affecting brain. Although exceptional progress have been obtained for exploring the brain during the past decades, it is still terra-incognita and calls for specific efforts in research to better understand its architecture and functioning. To take up this great challenge of modern science and to solve t...

Brain computer interfaces (BCI) provides a non-muscular channel for controlling a device through electroencephalographic signals to perform different tasks. The BCI system records the Electro-encephalography (EEG) and detects specific patterns that initiate control commands of the device. The efficiency of the BCI depends upon the methods used to process the brain signals and classify various p...

Metacognition, the ability to monitor one's own cognitive processes, is frequently assumed to be univocally associated with conscious processing. However, some monitoring processes, such as those associated with the evaluation of one's own performance, may conceivably be sufficiently automatized to be deployed non-consciously. Here, we used simultaneous electro- and magneto-encephalography (EEG...

BACKGROUND Behavioral paradigms applied during human recordings in electro- and magneto- encephalography (EEG and MEG) typically require 1-2 hours of data collection. Over this time scale, the natural fluctuations in brain state or rapid learning effects could impact measured signals, but are seldom analyzed. METHODS AND FINDINGS We investigated within-session dynamics of neocortical alpha (7...

Several lines of evidence suggest that deficits in γ-aminobutyric acid (GABA) inhibitory neurotransmission are implicated in the pathophysiology of schizophrenia, bipolar disorder, major depressive disorder and obsessive-compulsive disorder. Cortical inhibition refers to a neurophysiological process, whereby GABA inhibitory interneurons selectively attenuate pyramidal neurons. Transcranial magn...

The forward electro-encephalography (EEG) problem involves finding a potential V from the Poisson equation ∇·(σ∇V ) = f , in which f represents electrical sources in the brain, and σ the conductivity of the head tissues. In the piecewise constant conductivity head model, this can be accomplished by the Boundary Element Method (BEM) using a suitable integral formulation. Most previous work uses ...

OBJECTIVES An extensive neuroimaging literature on chronic pain demonstrates increased cerebral blood flow and metabolism consistent with increased neuronal activity in the structures comprising the "pain matrix"; furthermore, some of these regions have been shown to encode pain intensity. It is the objective of this study to demonstrate the feasibility of using quantitative electroencephalogra...

To disentangle taste from reward responses in the human gustatory cortex, we combined high density electro-encephalography with a gustometer delivering tastant puffs to the tip of the tongue. Stimuli were pure tastants (salt solutions at two concentrations), caloric emulsions (two milk preparations identical in composition except for fat content) and a mixture of high fat milk with the lowest s...

INTRODUCTION: Tuberous Sclerosis Complex (TSC), a genetic disorder with an incidence as high as 1/5000, leads to benign tumors in multiple organ systems. It causes epilepsy, autism, and neurocognitive delays. If antiepileptic medication is ineffective, seizures can be abolished with resection surgery if the onset region can be localized. Traditionally, the MRI-defined tuber has been the primary...

Electrophysiological modeling of Magnetoand Electro-encephalography (MEG and EEG) rely on accurate forward solvers that relate source activities to sensor measurements. In comparing a Boundary Element (BEM) and a Finite Element Method (FEM) for forward electroencephalography, in our early numerical experiments, we found the FEM to have a better accuracy than the BEM. This triggered a quest to i...