Cutaneous squamous cell carcinoma (cSCC) is the second most common form of skin cancer. Emerging evidence suggests that homeoproteins can act as modulators tumor initiation and progression in cSCC. DLX3 a homeobox transcription factor which plays pivotal roles embryonic development epidermal homeostasis. Previous work from our lab, using both human samples Dlx3 knock-out (Dlx3cKO) mouse model, ...

Pachyonychia congenita (PC) is a rare keratinizing disorder characterized by painful palmoplantar keratoderma (PPK), thickened nails and blistering for which there are no standard current treatment. PC caused dominant mutations in keratin 6A, 6B, 6C, 16 17 genes involved stress, wound healing epidermal barrier formation. Mechanisms leading to pain PPK remain elusive. To gain further insight int...

The expression of genes which may be involved in the regulation of human mammary epithelial cell growth [transforming growth factors alpha and beta] and tumorigenesis [c-myc, erbB2, epidermal growth factor receptor (EGFR), Ha-ras, pS2] has been compared in similarly cultured normal cell strains and tumor cell lines. We have found that the normal breast cells produce high levels of EGFR mRNA, wh...

Tumor tissue explants are an attractive tool for personalized predictive tests, however their use is compromised by subjective nature of morphological assessment drug response. We aimed to identify reporter genes, which rapidly change level expression in drug-sensitive but not drug-resistant tumors. Fresh tumor tissues were obtained from patients with non-small cell lung cancer (NSCLC) undergoi...

The gene most commonly altered in human glioblastomas is the epidermal growth factor receptor (EGFR). We profiled transcripts induced by mutant EGFR to better understand its role in tumor progression. The pattern found suggested enhanced tumor invasion. The highly induced genes included extracellular matrix components, metalloproteases, and a serine protease. We confirmed that mutant EGFR did m...

Eleven recently isolated erbB-transducing viruses as well as avian erythroblastosis virus (AEV)-R (ES4) and AEV-H have been characterized for the type of disease they cause, their ability to transform fibroblasts in culture, their ability to cause disease in pedigrees of chicken that differ in susceptibility to erbB-induced erythroblastosis, and the structure of their erbB genes. Differences in...

AIM To determine the incidences of copy number aberrations of receptor kinases and their relations in Turkish patients with gastric adenocarcinoma. MATERIALS AND METHODS The prevalence of genomic copy number aberrations of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2)/topoisomerase IIa (TOP2A), centrosome-associated kinase aurora A (AURK A), centroso...

Mortality after initial diagnosis of lung cancer is higher than from any other cancer. Although mutations in several genes, such as EGFR and K-ras, have been associated with clinical outcome, technical complexity, cost and time have rendered routine screening prohibitive for most lung cancer patients prior to treatment. In this study, using both novel and established technologies, we developed ...

Background. In the central nervous system, glioblastoma multiforme (GBM) is one of most important neoplasms in adults. Amplification EGFR and VEGF genes common GBM. However, role overexpression survival patients with GBM has been a contentious issue. Therefore, we performed present study to assess rate overexpression. Materials methods. Resected samples were evaluated by immunohistochemistry fo...

Non-small cell lung cancer (NSCLC) represents approximately 85% of all lung cancers, which are the leading cause of cancer-related deaths in the world. Tyrosine kinase inhibitors such as erlotinib represent one therapeutic options presently recommended for tumors produced by activating mutations in the gene coding of epidermal growth factor receptor (EGFR). The aim of this study is the identifi...