Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites that importantly contribute to vascular and cardiac physiology. The contribution of EETs to vascular and cardiac function is further influenced by soluble epoxide hydrolase (sEH) that degrades EETs to diols. Vascular actions of EETs include dilation and angiogenesis. EETs also decrease inflammation and platelet aggregation and in...

Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites of cytochrome P450 monooxygenase, which are released from endothelial cells and dilate arteries. Dilation seems to be caused by activation of large-conductance Ca2+ activated K+ channels (BK(Ca)) leading to membrane hyperpolarization. Previous studies suggest that EETs activate BK(Ca) channels via ADP-ribosylation of the G protei...

Paraoxonase 1 (PON1) is an antiatherogenic high density lipoprotein-associated lactonase. Recent findings revealed that PON1 knockout mice have low blood pressure, which is negatively correlated with the level of 5,6-epoxyeicosatrienoic acid (5,6-EET), a cytochrome P450 -derived arachidonic acid metabolite. 5,6-EET is an endothelium-derived hyperpolarizing factor that causes arterial dilation. ...

The extra element theorem (EET) states that any transfer function of a linear system can be expressed in terms of its value when a given “extra” element is absent, and a correction factor involving the extra element and two driving point impedances seen by the element. One class of applications is when a system has already been analyzed and later an extra element is to be added to the model: th...

The cytochrome P450 eicosanoid 14,15-epoxyeicosa-5,8,11-trienoic acid (14,15-EET) is a powerful endogenous autacoid that has been ascribed an impressive array of physiologic functions including regulation of blood pressure. Because 14,15-EET is chemically and metabolically labile, structurally related surrogates containing epoxide bioisosteres were introduced and have become useful in vitro pha...

The transport of electronic excitation energy (EET) between ions, atoms, molecules or chromophores is an important process that occurs in a wide range physical systems. tantalising prospect effective experimental control over such transfer is, principle, amenable to variety different kinds approach. Several the most promising, which are analysed and compared this paper, involve influence extern...

Eccentric ergometer training (EET) is increasingly being proposed as a therapeutic strategy to improve skeletal muscle strength in various cardiorespiratory diseases, due to the principle that lengthening muscle actions lead to high force-generating capacity at low cardiopulmonary load. One clinical population that may particularly benefit from this strategy is chronic obstructive pulmonary dis...

Campbell, William B., Blythe B. Holmes, John R. Falck, Jorge H. Capdevila, and Kathryn M. Gauthier. Regulation of potassium channels in coronary smooth muscle by adenoviral expression of cytochrome P-450 epoxygenase. Am J Physiol Heart Circ Physiol 290: H64–H71, 2006. First published September 2, 2005; doi:10.1152/ajpheart.00516.2005.—Epoxyeicosatrienoic acids (EETs) are endothelium-derived cyt...

Epoxyeicosatrienoic acids (EETs) relax various smooth muscles by increasing outward K+movement, but the molecular mode of action of EET regioisomers remains to be clarified. The effects of EETs were investigated on bovine airway smooth muscle tone and on reconstituted Ca2+-activated K+(KCa) channels. 5,6-EET and 11,12-EET induced dose-dependent relaxations of precontracted bronchial spirals. Th...