BRD4 is implicated in the pathogenesis of a number of different cancers. It is also the target of translocation t(15;19) that accounts for the highly aggressive NUT midline carcinoma (NMC). We discovered that t(15;19) NMC cells display the ability to grow into stem cell-like spheres and express an exceptionally high level of the stem cell marker, SOX2. The BRD4-NUT fusion oncogene resulting fro...

In alternative medicine, medicinal plant preparations have found widespread use particularly in the case of diseases not amenable to treatment by modern methods. Chemical and phytochemical analyses of Semecarpus anacardium nut reveal the presence of biflavonoids, phenolic compounds, bhilawanols, minerals, vitamins and amino acids. A variety of nut extract preparations from this source are effec...

BACKGROUND Nuclear protein in testis (NUT) midline carcinomas (NMC) are rare, highly aggressive epithelial neoplasms, characterised by protein expression of NUT-fusion proteins which reflects the genetic translocation between chromosome 15 and 19. NMC occurs mainly in midline structures, but there are reports regarding occurrence in structures outside the midline. We investigated specimens from...

The areca nut, fruit of the oriental palm (Areca catechu), also called 'betel' nut in English, supari in Hindi, adike or betta in Kannada, adakka in Malayalam, and pakku in Tamil, is commonly used in India (FRLHT.org, 2015) and needs no introduction. It is used in traditional quids (beeda) wrapped in betel leaves (Piper betle) or as tobacco and areca nut mixtures. Areca nut is also used per se ...

Sustainable exploitation is widely advocated as a strategy for reconciling economic pressures upon natural habitats with nature conservation. Two recent papers examine different aspects of the sustainability of the nut harvest on wild populations of Brazil nut trees Bertholletia excelsa in Amazonia. Peres et al. find that many populations of the Brazil nut tree lack juvenile trees and are not r...

I present NUT, a tool for understanding the nutritional content of what we eat. The project consists of a rapid prototyping and analysis phase, as well as a design study documenting the development of the NUT prototype. The goal of NUT is to support users in making healthy choices about what to eat by visualizing nutritional information in the context of the whole food. This report outlines the...

In a subset of poorly differentiated and highly aggressive carcinoma, a chromosomal translocation, t(15;19)(q13;p13), results in an in-frame fusion of the double bromodomain protein, BRD4, with a testis-specific protein of unknown function, NUT (nuclear protein in testis). In this study, we show that, after binding to acetylated chromatin through BRD4 bromodomains, the NUT moiety of the fusion ...

Chinese torreya nut (Torreya grandis cv. Merrillii) is a unique edible that grows in China, which known for its ability to reduce blood lipids, prevent sclerosis, and coronary heart disease. However, effect on reproduction not well understood. In this study, the comprehensive effects of sex hormones endometrium female mice their uterine expression profiles were investigated. Here, feeding with ...

Gene expression in lambdoid phages in part is controlled by transcription antitermination. For most lambdoid phages, maximal expression of delayed early genes requires an RNA polymerase modified by the phage N and host Nus proteins at RNA NUT sites. The NUT sites (NUTL and NUTR) are made up of three elements: BOXA, BOXB and an intervening spacer sequence. We report on N antitermination in H-19B...

Areca nut (seed of Areca catechu) is consumed by people from different parts of Asia, including India. The four major alkaloids present in areca nut are arecoline, arecaidine, guvacoline and guvacine. Upon cutting, the nut reveals two kinds of regions; white and brown. In our present study, we have monitored the formation of these two regions within the nut during maturation, using the non-inva...