BACKGROUND AND PURPOSE White matter injury caused by cerebral hypoperfusion may contribute to the pathophysiology of vascular dementia and stroke, but the underlying mechanisms remain to be fully defined. Here, we test the hypothesis that oxidative stress interferes with endogenous white matter repair by disrupting renewal processes mediated by oligodendrocyte precursor cells (OPCs). METHODS ...

Bipolar disorder is a chronic disease characterized by recurring episodes of mania and depression that can lead to disability. This study investigates the protective effects of edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a drug with well-known antioxidant properties, in a model of mania induced by ketamine in rats. Locomotor activity was assessed in the open-field test. Superoxide dismutas...


 CADTH recommends that Radicava should be reimbursed by public drug plans for the treatment of patients with amyotrophic lateral sclerosis (ALS), if certain conditions are met.
 oral suspension only covered to treat ALS provided it is a similar patient population and in way IV formulation adult ALS.
 prescribed manner as prescribed, cost does not exceed program Radicava.

IMPORTANCE Although herpes simplex virus type 1 (HSV-1) is a causative agent of Bell palsy, the precise mechanism of the paralysis remains unknown. It is necessary to investigate the pathogenesis and treatment of Bell palsy due to HSV-1 infection. OBJECTIVE This study elucidated the role of nitric oxide (NO) in the incidence of facial nerve paralysis caused by HSV-1 in mice and to evaluate th...

The aim of the study was to investigate the clinical effect of urinary kallidinogenase combined with edaravone in the treatment of massive cerebral infarction. A total of 58 patients with massive cerebral infarction were admitted to hospital between January 2013 and January 2014. There were 34 male and 24 female patients. The patients were randomly divided into the observation and control group...

Objective: Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disorder that causes progressive loss of the upper and lower neurons in brain spinal cord. SOD1 was first gene linked to ALS, which more than 150 mutations throughout sequence protein have been found be associated with ALS. Methods: The drugs can interact inhibit misfolding or revert misconformation useful treatment Monomer ...

0014-4886/$ – see front matter © 2009 Elsevier Inc. Al doi:10.1016/j.expneurol.2009.03.001 ⁎ Fax: +81 75 761 9780. E-mail address: [email protected]. Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder characterized by progressive and relatively selective degeneration of upper and lower motor neurons. Patients suffer from atrophy and paralysis of systemic v...

Oxidative stress plays a pivotal role in developing and accelerating retinal diseases including age-related macular degeneration (AMD), glaucoma, diabetic retinopathy (DR), and retinal vein occlusion (RVO). An excess amount of reactive oxygen species (ROS) can lead to functional and morphological impairments in retinal pigment epithelium (RPE), endothelial cells, and retinal ganglion cells (RGC...

BACKGROUND Edaravone is widely used for treating ischemic stroke, but it is not still confirmed in intracerebral hemorrhage (ICH) as an ideal medication targeting the brain parenchyma. We aimed to investigate the neuroprotective effects of stereotactic administration of edaravone (SI) into the brain parenchyma. METHODS Intracerebral hemorrhage rat models were established by infusion of collag...

OBJECTIVE To explore the effects of edaravone on the expression of matrix metalloproteinase-9 (MMP-9) posterior to cerebral hemorrhage, and to analyze the relationship between this expression and neurological deficit. METHODS A total of 160 basal ganglia hemorrhage patients enrolled in Dongfeng Hospital, Hubei University of Medicine, Shiyan, China between April 2009 and July 2011 were include...