نتایج جستجو برای: ed50

تعداد نتایج: 1587  

2005
Gyu - Yong SONG Dong - Hee KIM Mi - Young YOON Byung - Zun AHN

and is an endemic species in Korea. The roots of this plant have been widely used in traditional medicine for the treatment of several diseases, particular malaria and amoebic dysentery. This plant has been investigated extensively, resulting in the isolation of various saponins, ranunculin, anemonin, protoanemonin and triterpenes. Our continuing investigation of the chemical constituents of th...

Journal: :Anesthesiology 2004
Yehuda Ginosar Edward Mirikatani David R Drover Sheila E Cohen Edward T Riley

BACKGROUND Successful cesarean delivery anesthesia has been reported with use of small doses (5-9 mg) of intrathecal bupivacaine coadministered with opioids. This double-blind, randomized, dose-ranging study determined the ED50 and ED95 of intrathecal bupivacaine (with adjuvant opioids) for cesarean delivery anesthesia. METHODS Forty-two parturients undergoing elective cesarean delivery with ...

Journal: :Anesthesiology 2000
M M Puig W Warner O Pol

BACKGROUND Morphine and clonidine show synergy or antagonism inhibiting gastrointestinal transit depending on their proportion and level of effect. Their interaction during morphine tolerance and intestinal inflammation were assessed. METHODS Gastrointestinal transit in mice was evaluated with charcoal and antitransit effects expressed as percent mean values +/- SEM. Tolerance was induced wit...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه زابل - دانشکده کشاورزی 1387

مشکلات عمده ناشی از مصرف مداوم سموم شیمیایی روز به روز در حال افزایش است. از جمله آن ها می توان به مقاومت آفات در مقابل این سموم ، اثر منفی روی دشمنان طبیعی و اکوسیستم و در خطر افتادن سلامتی انسان می توان اشاره کرد. کشف ترکیبات جدید که انتخابی عمل کند و دوام کمتری نیز در محیط داشته باشد، هم برای محیط زیست و هم برای مصرف کنندگان مواد غذایی کشاورزی فواید زیادی را به همراه دارد. علاوه بر متابولیت ...

Journal: :Anesthesiology 2001
S Saito I Radwan H Obata K Takahashi F Goto

BACKGROUND Local anesthetics have direct neurotoxicity on neurons. However, precise morphologic changes induced by the direct application of local anesthetics to neurons have not yet been fully understood. Also, despite the fact that local anesthetics are sometimes applied to the sites where peripheral nerves may be regenerating after injury, the effects of local anesthetics on growing or regen...

Journal: :Anesthesiology 2002
Kenneth E Nelson Traci Rauch Victor Terebuh Robert D'Angelo

BACKGROUND The use of intrathecal opioids for labor analgesia continues to gain popularity, but there are limited data to guide this use. Previously, the authors established the ED50 for 60 min of labor analgesia from intrathecal sufentanil using an up-down sequential allocation study design. The current study first establishes an ED50 for intrathecal fentanyl using this same study design to es...

Journal: :Toxicology and applied pharmacology 1990
B J Smith D R Mattison I G Sipes

4-Vinylcyclohexene (VCH) is present in gases discharged during synthetic rubber production. Chronic treatment of B6C3F1 mice and F-344 rats with VCH by gavage has been shown to induce ovarian tumors in mice but not in rats. Our objective was to understand the mechanism of the species difference in VCH-induced ovarian tumors. Since a critical step in the induction of ovarian tumors is destructio...

Journal: :iranian journal of pharmaceutical research 0
xian-qing deng yanbian university ming-xia song yanbian university shi-ben wang yanbian university zheshan quan college of pharmacy, yanbian university

epilepsy is the most frequnt nearological affiction and afflicts 1% about of the worlds population. currently there is an urgent need for the development of novel anticonvulsants with higher levels of potency and lower levels of toxicity. in this paper, a series of new 6-(substituted-phenyl)thiazolo[3,2-b][1,2,4]triazole derivatives were synthesized and tested for their anticonvulsant activity ...

Journal: :The Journal of pharmacology and experimental therapeutics 2014
Kenji Maeda Linda Lerdrup Haruhiko Sugino Hitomi Akazawa Naoki Amada Robert D McQuade Tine Bryan Stensbøl Christoffer Bundgaard Jørn Arnt Tetsuro Kikuchi

Brexpiprazole (OPC-34712, 7-{4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy}quinolin-2(1H)-one) is a novel serotonin-dopamine activity modulator with partial agonist activity at serotonin 1A (5-HT1A) and D2/3 receptors, combined with potent antagonist effects on 5-HT2A, α1B-, and α2C-adrenergic receptors. Brexpiprazole inhibited conditioned avoidance response (ED50 = 6.0 mg/kg), apomorphine- ...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید