Organic synthesis plays the central role in the process of drug design and development. Retrosynthetic analysis represents a very powerful tool for designing convergent and economical synthetic routes of targeted drugs. In this paper, we report some synthetic protocols for a potent anti-obesity agent ‘Sibutramine’ in a novel way basing on retrosynthetic analysis. The proposed synthesis schemes ...

Succinic acid is identified to have a great economical potential in a biobased economy. To improve the production in Escherichia coli metabolic engineering should be carried out. For new mutant strain design is important to in silico simulate and analyze the metabolic changes, network of a cell under different environmental and/or genetic perturbations. To investigate the genetic and environmen...

BACKGROUND The classical Strecker reaction is one of the simplest and most economical methods for the synthesis of racemic α-aminonitriles (precursor of α-amino acids) and pharmacologically useful compounds. RESULTS Indium powder in water is shown to act as a very efficient catalyst for one-pot, three-component synthesis of α-aminonitriles from diverse amines, aldehydes and TMSCN. This genera...

Biodiesel industry requires a cheaper and economical viable raw material that can replace the vegetable oil. Waste from animal and plant sources became the main option due the availability and cheap. In this study, coconut waste is used to produce biodiesel using methanol, acid sulfuric and KOH. In situ process is used, where all the catalyst, reagent and raw material is mixed together in one s...

Fusarium head blight, one of the most destructive diseases of wheat (Triticum aestivum L.), results in significant economic losses from reduced grain yield and quality. In recent decades, the disease has been frequently recorded, especially under warm and wet climatic conditions. Genetic resistance has engaged plant breeders because the use of resistant cultivars is the most economical, effecti...

Serratia marcescens strain 9986 is a producer of prodigiosin used as a dye of polyolefines (polyethylene, ultratene). The biosynthesis of pigment was closely connected with controlled growth parameters. A prodigiosin yield 0.2 0.4 mg per l of culture medium in the batch culture under aerobic conditions was obtained. Prodigiosin was extracted from crude biomass treated by 0.1% of sodium dodecyl ...

Genetic improvement programs in dairy cattle have until recently focused on increasing net profit by increasing gross income per cow, rather than reducing costs of production [1]. Strong selection pressure on yield traits coupled with management practices aimed at maximizing production may have resulted in undesirable side effects related to decreased fitness [2]. These concerns have been confi...

Recently, "superbinder" SH2 domain variants with three amino acid substitutions (sSH2) were reported to have 100-fold or greater affinity for protein-phosphotyrosine (pY) than natural SH2 domains. Here we report a protocol in which His-tagged Src sSH2 efficiently captures pY-peptides from protease-digested HeLa cell total protein extracts. Affinity purification of pY-peptides by this method sho...

in order to compare of ecological management of weed control on economical income, yield and yield components of cotton (gossypium hirsutum l.), a randomized complete block design with 12 treatments and four replications was conducted in mahvelat of khorasan razavi province, iran. treatments consisted of weeding, harrowing, burning, two times weeding, weeding + harrowing, weeding + burning, har...

sustainable economical production of tea depends on the proper use of water and fertilizer. for this purpose, the role of supplemental irrigation and nitrogen fertilizer on economical production of tea plantations was studied by assessment of yield, production function, water use efficiency, and benefit/cost ratio, and final return in a field experiment at feshalam tea research station in fouma...