Nearly 50% of women experience at least one urinary tract infection (UTI) in their lifetime. Studies with mice have revealed that uropathogenic Escherichia coli (UPEC) isolates invade superficial umbrella cells that line the bladder, allowing them to find a safe haven and subvert clearance by innate host responses. Rapid intracellular replication results in the formation of distinctive intracel...

Urinary tract infections (UTIs) are common in women, and recurrence is a major clinical problem. Most UTIs are caused by uropathogenic Escherichia coli (UPEC). UPEC are generally thought to migrate from the gut to the bladder to cause UTI. UPEC form specialized intracellular bacterial communities in the bladder urothelium as part of a pathogenic mechanism to establish a foothold during acute st...

Urinary tract infection (UTI) caused by uropathogenic Escherichia coli (UPEC) is a substantial economic and societal burden-a formidable public health issue. Symptomatic UTI causes significant discomfort in infected patients, results in lost productivity, predisposes individuals to more serious infections, and usually necessitates antibiotic therapy. There is no licensed vaccine available for p...

Uropathogenic Escherichia coli (UPEC) are the primary causative agents of urinary tract infections. Some UPEC isolates are able to infect renal proximal tubule cells, and can potentially cause pyelonephritis. We have previously shown that to fulfill their physiological roles renal proximal tubule cells accumulate high concentrations of α-ketoglutarate (KG) and that gene cluster c5032-c5039 cont...

In the remote Japanese community of Saku, a rural town in the Nagano Prefecture, a large proportion of outpatient urinary tract infections was caused by well-recognized globally dispersed clonal lineages of uropathogenic Escherichia coli (UPEC). However, most of these strains were drug susceptible, suggesting that factors other than selection pressure account for the clonal spread of drug-susce...

conclusions the results of this study indicated that more than 90% of e. coli isolates harbored the fimh gene. the high binding ability of fimh could result in the increased pathogenicity of e. coli; thus, fimh could be used as a possible diagnostic marker and/or vaccine candidate. materials and methods a total of 140 isolated e. coli strains from patients with uti were identified using biochem...

Objective(s): Regarding the global burden of uropathogenic Escherichia coli (UPEC) infections, prevention and treatment of such infections play a significant role in healthcare management. The inordinate use of fluoroquinolones led to a worldwide spread of quinolone-resistant strains. Therefore, this study aimed to investigate mutations in codons 83 and 106 of gyrA gene in UPEC isolates in the ...

At least 300 million urinary tract infections (UTIs) occur annually worldwide. Uropathogenic Escherichia coli (UPEC) are the leading cause of UTIs. The discovery antibiotics has revolutionised modern medicine. Yet, overusing accelerated emergence antimicrobial resistance (AMR), with UPEC driving dissemination AMR globally. Resistance to broad-spectrum like third-generation cephalosporins (3GCs)...

Background Escherichia coli is among the most common uropathogens. Increased antibiotic resistance in Gram negative bacilli global concern. Alternative therapeutic options including vaccines against uropathogenic E. (UPEC) have been developed. In this study, we compared genotypic characteristics and antimicrobial susceptibility of UPEC according to phylogenetic groups. Methods We retrospectivel...

Urinary tract infections (UTIs) are the second most common bacterial infection with high recurrence rates and can involve biofilm formation on patient catheters. Biofilms inherently tolerant to antimicrobials, making them difficult eradicate. Many antibiofilm agents alone do not have bactericidal activity; therefore, linking antibiotics is a promising strategy. However, many of these hybrid bee...