Sonic hedgehog, a secreted signalling molecule known to play a role in the patterning of the central nervous system and the limb in vertebrates, also controls differentiation of the somites.

Signaling molecules such as Activin, Sonic hedgehog, Nodal, Lefty, and Vg1 have been found to be involved in determination of left-right (L-R) asymmetry in the chick, mouse, or frog. However, a common signaling pathway has not yet been identified in vertebrates. We report that Pitx2, a bicoid-type homeobox gene expressed asymmetrically in the left lateral plate mesoderm, may be involved in dete...

nowadays, using natural preservatives than synthetic ones is increasing. the present study was aimed to compare the effect of thyme (zataria multiflora boiss), onion (allium cepa) and ziziphora clinopodioides extracts on shelf-life extending of rainbow trout (oncorhynchus mykiss) salted, vacuum packaged fillet, kept at 4°c. for this purpose fish filets were kept in 4 treatment: salted in brine ...

It is important to quantify patterns of morphological diversity to enhance our understanding of variation in ecological and evolutionary traits. Here, we present a quantitative analysis of morphological diversity in a family of small mammals, the tenrecs (Afrosoricida, Tenrecidae). Tenrecs are often cited as an example of an exceptionally morphologically diverse group. However, this assumption ...

Scube2 enhances proteolytic Shh processing from the surface of producing cells 1 2 Petra Jakobs*, Sebastian Exner*, Sabine Schürmann*, Ute Pickhinke, Shyam 3 Bandari, Corinna Ortmann, Sabine Kupich, Philipp Schulz, Uwe Hansen, Daniela G. 4 Seidler & Kay Grobe 5 6 From the Institute for Physiological Chemistry and Pathobiochemistry, Westfälische 7 Wilhelms Universität Münster, Waldeyerstr. 15, D...

Upon reaching their intermediate target, the floorplate, commissural axons acquire responsiveness to repulsive guidance cues, allowing the axons to exit the midline and adopt a contralateral, longitudinal trajectory. The molecular mechanisms that regulate this switch from attraction to repulsion remain poorly defined. Here, we show that the heparan sulfate proteoglycan Glypican1 (GPC1) is requi...

Recent work from Agarwala et al. has uncovered exquisite ventral patterning in the mesencephalon. Using electroporation in chicks, they show that ectopic expression of Sonic Hedgehog (Shh) in dorsal mesencephalon can recapitulate this patterning in its entirety. These results are discussed in the context of the purported role of Shh as a morphogen.

We have isolated a new chicken gene, cBarx2b, which is related to mBarx2 in sequence, although the expression patterns of the two genes are quite different from one another. The cBarx2b gene is expressed in craniofacial structures, regions of the neural tube, and muscle groups in the limb, neck and cloaca. Perturbation of anterior muscle pattern by application of Sonic Hedgehog protein results ...