Neonatal sepsis continues to be a common and significant health care burden, especially in very-low-birth-weight infants (VLBW<1500 g). Though intrapartum antibiotic prophylaxis has decreased the incidence of early-onset group B streptococcal infection dramatically, it still remains a major cause of neonatal sepsis. Moreover, some studies among VLBW preterm infants have shown an increase in ear...

Sepsis, and related complications, is still a common cause of death in hospitalized patients worldwide, especially in critically ill neonates and children. Sepsis is also responsible for significant morbidity, and financial burden. It is very important to recognize sepsis early, since delayed diagnosis is associated with worse outcome. The early detection of sepsis remains a great challenge for...

The early sequence of events leading to the development of the acute respiratory distress syndrome (ARDS) in patients with sepsis remains inadequately understood. The purpose of this study was to identify changes in gene expression early in the course of illness, when mechanisms of injury may provide the most relevant treatment and prognostic targets. We collected whole blood RNA in critically ...

Results: We found high percentage of expression of CD64 on neutrophils in patients (67.73 ± 24.74) when compared with controls (8.19 ± 3.64) and also their percentage of expression was higher in culture positive sepsis (76.25 ± 29.07) than culture negative sepsis (42.21 ± 33.24). In the present study, I/T ratio >0.2 had a sensitivity, specificity, PPV, NPV and accuracy i.e. 70.0%, 72.0%, 33.3%,...

OBJECTIVE To evaluate utility of C-reactive protein (CRP) in the early diagnosis of neonatal sepsis in a tertiary care Newborn Unit in Kenya. DESIGN Cross-sectional study. SETTING Newborn Unit, Kenyatta National Hospital. SUBJECTS All neonates admitted to Newborn Unit, Kenyatta National Hospital during the study period with suspected sepsis based on specified clinical criteria. RESULTS ...

Abstract Objective Sepsis is a major cause of mortality for critically ill patients. This study aimed to determine whether presepsin values can predict in patients with sepsis. Results Receiver operating characteristic (ROC) curve analysis, Log-rank test, and multivariate analysis identified Prognostic Nutritional Index as predictors sepsis Presepsin value on Day 1 was predictor early mortality...

Hospital Physician June 2007 21 Sepsis is a common condition that is associated with poor patient outcomes and high financial costs. An estimated 750,000 cases of sepsis occur each year. Because sepsis is more common in elderly patients, its incidence is expected to rise as the US population ages.1 Despite recent advances in management and therapy, the mortality rate from severe sepsis remains ...

Altered phosphorylation and Ca(2+) sensitivity of cardiac myofibrillar proteins during different phases of sepsis were investigated. Sepsis was induced by cecal ligation and puncture (CLP). The results show that phosphorylation of troponin I (TnI) was increased by 268% during the early phase (9 h after CLP) but decreased by 46% during the late phase (18 h after CLP) of sepsis. Phosphorylation o...