Mitotic divisions result from the oscillating activity of cyclin-dependent kinase 1 (Cdk1). Cdk1 activity is terminated by the anaphase-promoting complex/cyclosome (APC/C), a ubiquitin ligase that targets cyclin B for destruction. In somatic divisions, the early mitotic inhibitor 1 (Emi1) and the spindle assembly checkpoint (SAC) regulate cell cycle progression by inhibiting the APC/C. Early em...

This study examined the relationship of catastrophizing to fatigue in 80 women receiving chemotherapy (CT) or radiotherapy (RT) for treatment of early stage breast cancer. Findings revealed expected relationships between catastrophizing and fatigue among women receiving RT but not CT. Among RT patients, those high in catastrophizing reported significantly greater fatigue than was reported by th...

BACKGROUND AND PURPOSE Pain is currently evaluated with "subjective" methods (eg, patient self-report). This study aimed to test whether fatigue indexes are able to accurately discriminate between subjects with and subjects without low back pain. SUBJECTS Sixty subjects separated into 2 groups--a group with low back pain (n=30) and a group without low back pain (n=30)--participated in this st...

in islamic texts, waqf of money was restricted to dirham and dinar, for the only prevailing money in early islam has been these two kinds. definitions of waqf presented by jurists as “imprisoning the concrete property” resulted in restriction of waqf to those things benefitting of which would not lead to their destruction. consequently, expanding the scope of waqf became almost impossible. as t...

Fatigue damage accumulation under variable amplitude loadings is vital for the life prediction of welded structures. An approach based on distribution mapping presented. S-N curves joints are utilized to construct fatigue zones, and a corresponding polynomial fitting function derived from heat transfer FEA solution. Experimental results cruciform T tensile three-point bending employed validatio...

BACKGROUND Ankylosing spondylitis (AS) is characterised by immune-mediated arthritis and osteoproliferation, ultimately leading to joint ankylosis. Whether inflammation is necessary for osteoproliferation is controversial, fuelled by the unclear efficacy of anti-inflammatory treatments on radiographic progression. In proteoglycan-induced spondylitis (PGISp), a mouse model of AS, inflammation is...

Several psychological issues are associated with excessive use of social media, including anxiety, Social Media Fatigue, and Fear Missing Out (FOMO). Therefore, this research aimed to examine the mediating role FOMO between anxiety Fatigue. The quantitative analysis involved 224 early adulthood individuals as participants, using Generalized Anxiety Disorder, Scales instruments. path result show...

The change in the structural state of gas pipes’ weld material at different seam cross-sections have been considered. classification external and internal defects joint caused by influence types factors, most significant which are transition zone to pipe base metal. analysis atmospheric effects on pipeline welds materials initiating adsorption electrochemical processes metal microstructure that...

OBJECTIVE To determine the effects of fatigue during an external rotation task on 3-dimensional scapular kinematics. DESIGN A single-group, pretest-posttest measurement design. SETTING Research laboratory. PARTICIPANTS Thirty healthy subjects. INTERVENTIONS Not applicable. MAIN OUTCOME MEASURES Three-dimensional scapular kinematics were recorded with a Polhemus magnetic tracking devic...

The purpose of the present paper was to analyze the efficiency of an abbreviated, albeit objective posturographic test as an indicator of fatigue. Posturography was measured in 10 healthy adults (age 18-33 years, male/female 7/3). Baseline posturographic measurements were taken for each subject. Later, a shorter (3-min) posturographic test was administered 12 times during 25 h of sleep deprivat...