BACKGROUND Because of the relatively similar size of organs to human and the physiological and structural similarities, the use of porcine as xenograft donors is progressing very actively. In this study, we analyzed the characteristics of porcine ear cartilage and evaluated its suitability as graft material in reconstructive and cosmetic surgery. METHODS The auricular cartilage was harvested ...

HYPOTHESIS The osseointegrative capacity of medical-grade bone cement can be used to improve fixation and prevent displacement of an ossicular prosthesis in a guinea pig model. BACKGROUND Successful ossiculoplasty requires a firm connection between the vibrating tympanic membrane and the inner ear. In patients requiring revision ossiculoplasty, half of failures are due to prosthesis displacem...

Acute Otitis Media (AOM) is one of the most common ear diseases. It is an inflammation within the middle ear cleft, located behind an intact tympanic membrane. Patients with AOM may exhibit symptoms and signs specific to ear disease, including pain, fever, bulging tympanic membrane, middle ear effusion, otorrhea and hearing loss [1]. Uncommon symptoms and signs of AOM include hearing loss, tinn...

Objectives: The present study was carried out to evaluate the antiinflammatory effect of extracts of leaves of Vitex trifolia Linn. (Verbaneaceae). Methods: The anti inflammatory activity of plant extracts at different dose intervals was evaluated by using two models Carrageenan induced rat paw edema and Xylene induced ear edema in Mice. Acute inflammation in rats was induced by injecting Carra...

BACKGROUND Lysozyme is an antimicrobial innate immune molecule degrading peptidoglycan of the bacterial cell wall. Lysozyme shows the ubiquitous expression in wide varieties of species and tissues including the tubotympanum of mammals. We aim to investigate the effects of lysozyme depletion on pneumococcal clearance from the middle ear cavity. METHODS Immunohistochemistry was performed to loc...

The anti-inflammatory effect of physalin E, a seco-steroid isolated from Physalis angulata L. was evaluated on acute and chronic models of dermatitis induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and oxazolone, respectively, in mouse ear. The changes in ear edema/thickness, production of pro-inflammatory cytokines (TNF-alpha and IFN-gamma), myeloperoxidase (MPO) activity, and histologi...

In the absence of any acute otological symptoms including pain and temperature, a middle ear effusion in association with hearing loss has been designated by various names, i.e. catarrhal otitis, exudation otitis, serous otitis, nonsuppurative otitis, glue ear, and currently the most fashionable terms, otitis media with effusion and secretory otitis media. A middle ear effusion without inflamma...

Since I introduced the homograft transplantation en bloc in 1959, more than 2,400 patients with chronic middle-ear inflammation and the conditions resulting from an old radical operation have been operated upon. Different kinds of chemical solution for the conservation of the homograft have been used, and experience has shown that the best solution is a combination of Cialit 1:5,000 and formald...

BACKGROUND Contact hypersensitivity (CHS) is a local inflammatory response of the skin following challenge of hapten-sensitized animals. It is the consequence of cell infiltration of derm and the release of inflammation mediators, among which Tumor necrosis factor-alpha (TNF-alpha) is one of the most important factors. The intensity of the inflammation could be quantified by ear swelling which ...