Cinnamic acid sugar ester derivatives (CASEDs) are a class of natural product with one or several phenylacrylic moieties linked with the non-anomeric carbon of a glycosyl skeleton part through ester bonds. Their notable anti-depressant and brains protective activities have made them a topic of great interest over the past several decades. In particular the compound 3',6-disinapoylsucrose, the i...

BACKGROUND TNF-α is an inflammatory cytokine that plays an important role in insulin resistance observed in obesity and chronic inflammation. Many cellular components involved in insulin signaling cascade are known to be inhibited by TNF-α. Insulin receptor substrate (IRS)-1 is one of the major targets in TNF-α-induced insulin resistance. The serine phosphorylation of IRS-1 enables the inhibiti...

Phlogacanthus cornutus is a rare species and the chemical profiles bioactivities of this plant are unknown. In present study, components acetone extract as well antioxidant activity its fractions such n-hexane, chloroform ethyl acetate P. were firstly reported. A total 33 constituents identify in using Gas Chromatography/Mass Spectrometry assay, which trans-cinnamic acid (21.26%), neophytadiene...

Thiazolidinediones improve insulin sensitivity in type 2 diabetes mellitus by acting as peroxisome proliferator-associated receptor gamma (PPARgamma) agonists, and decrease circulating androgen concentrations in polycystic ovary syndrome by unknown mechanisms. Some thiazolidinediones directly inhibit the steroidogenic enzymes P450c17 and 3beta-hydroxysteroid dehydrogenase type II (3betaHSDII) b...

In 2008 the efficacy of three environmentally friendly substances against apple aphid (Aphis pomi) was tested. The selected substances were cinnamic acid and two plant extracts, namely glicolic extract of comfrey (Symphytum officinale) and fluid extract of marigold (Calendula officinalis). All of the substances were tested at 0.5, 1 and 5 % concentrations. The individuals of apple aphids were c...

Subfractionation of Microsomes, Cell Suspension Culture, PAL, Cinnamic Acid p-Hydroxylase 1. The time course of activity of soluble and microsomal phenylalanine ammonia-lyase (PAL) was studied in dark grown cell cultures of soybean (Glycine max). A distinct activity increase of PAL in the soluble and microsomal fraction occurred prior to the stationary phase of the cell culture. Cinnamic acid p...

Tuberculosis (TB) is a threat to worldwide public health, mainly caused by Mycobacterium tuberculosis (M.tb.) bacteria species. Despite the availability of effective treatment, tuberculosis is responsible for more than three million deaths annually worldwide. The high susceptibility of human immunodeficiency virus-infected persons to the disease (Nunn et al., 2005), the emergence of multi-drug-...