Objective: To demonstrate how a single intra detrusor botulinum toxin injection could be responsible for lower limbs proximal motor deficit. Results: Two women-37 and 38 years old-presenting with secondary progressive multiple sclerosis, having received intra detrusor botulinum toxin injections (400 BOTOX® U and 750 DYSPORT® U) due to major neurogenic detrusor over activity with high-pressure a...

OBJECTIVE The aim of the study was to report physician experience-based "real-world" treatment patterns with botulinum toxin type A in patients with stroke and traumatic brain injury. DESIGN A prospective, multicenter, international observational registry design was used. RESULTS Six hundred twenty-seven participants with stroke and 132 participants with traumatic brain injury were assessed...

OBJECTIVE Although calf muscle spasticity is often treated with botulinum toxin type-A, the effects on balance and gait are ambiguous. Hereditary spastic paraplegia is characterized by progressive spasticity and relatively mild muscle weakness of the lower limbs. It is therefore a good model to evaluate the functional effects of botulinum toxin type-A. DESIGN Explorative pre-post intervention...

AIM To determine if botulinum toxin type A (BoNT-A) injections can reduce the frequency and severity of migraines. METHODS Patients (n = 127) were randomized to receive placebo or two doses of BoNT-A (Dysport). The primary endpoint was reduction in number of migraine attacks up to week 8 and between weeks 8 and 12 after injection. Patient diaries were used to record secondary endpoints, inclu...

Synopsis of Video Botulinum Toxin A (BTxA) is used widespread in neurology and plastic surgery with very good results. Some groups used BTxA for the treatment of detrusor hyperreflexia in spinal cord injury. We propose BTxA in children with incomplete spinal lesion and detrusor hyperreflexia refractory to anticholinergic medication, where bladder augmentation is the only alternative. We enrolle...

OBJECTIVE The aim of this study was to investigate the effect of botulinum toxin type A injection into the adductor muscles in reducing pain and improving joint mobility and quality of life in patients affected by hip osteoarthritis. METHODS A total of 39 outpatients, mean age 68 years (age range 41-82 years), were evaluated using the Harris Hip Score to test hip function, a visual analogue s...

BACKGROUND Neck dissection surgery is often followed by chronic head and neck pain. To date optimal treatment of this type of pain is lacking. Botulinum toxin type A (BTX-A) has been shown to be effective in the treatment of myofascial pain syndrome and headache. In a pilot study, we wanted to test the effectiveness of BTX-A for the treatment of chronic neck pain after neck dissection. METHOD...