OBJECTIVE Recent studies indicate that WT1 and Bcl2 protein are detected in melanocytic lesions of the skin. We examined, for the first time, WT1 and Bcl2 expression in a variety of conjunctival melanocytic lesions to evaluate their diagnostic utility compared with other melanocytic markers. METHODS Protein expression and localization of WT1 and Bcl2 were studied by means of immunolabeling an...

IMPORTANCE Patient-driven mobile teledermoscopy may be applicable for monitoring of skin lesions. OBJECTIVE To assess the feasibility, efficacy, and patient receptivity of teledermoscopy for short-term monitoring of clinically atypical nevi. DESIGN, SETTING, AND PARTICIPANTS This was a prospective cohort study performed at an institutional referral center in New York. Consecutive patients 1...

During the past few decades, scientific data relating to melanoma have flourished. New information regarding acquired nevi, dysplastic nevi (atypical nevi), and congenital nevi has given us a better understanding of these precursor lesions and their relationships to malignant melanoma. The roles of laboratory testing, photography, and newer diagnostic tools (eg, epiluminescence) to evaluate pat...

OBJECTIVES To identify risk factors and the prognosis associated with the development of multiple primary melanoma (MPM). DESIGN Case-comparison studies of subjects with MPM and single primary melanoma. Sequencing of CDKN2A in germline DNA. SETTING Population-based study of patients with invasive melanoma in Scotland between 1979 and 1996. PATIENTS For mortality studies, 108 patients with...

Cyclins play a fundamental role in the cell cycle. Recent studies have focused on their role in the development of various malignancies. The objective of this study was to evaluate and compare the expression of cyclins A and E in common nevi, dysplastic nevi and malignant melanomas, and to investigate the relationship between cyclin expression and some pathological parameters such as tumor thic...

Homogeneous nucleation of NAD and NAT in liquid stratospheric aerosols: insufficient to explain denitrification D. A. Knopf, T. Koop, B. P. Luo, U. G. Weers, and T. Peter Institute for Atmospheric and Climate Science, Swiss Federal Institute of Technology, Zurich, Switzerland Received: 18 April 2002 – Accepted: 13 May 2002 – Published: 12 June 2002 Correspondence to: D. A. Knopf (Daniel.Knopf@a...

Merkel cell carcinoma (MCC) is a rare yet highly aggressive tumour of the skin. While the dangers of other skin cancers like malignant melanoma are ingrained in most physicians’ minds—with the changing or atypical nevus often inciting an urgent biopsy—MCC remains an unfamiliar and neglected disease. Yet, the annual incidence of MCC is rising more quickly than that of melanoma, at 8% annually, a...

We study dynamical gauge symmetry breaking via compactified space in the framework of SU(N) gauge theory in M × S (d = 4, 5, 6) space-time. In particular, we study in detail the gauge symmetry breaking in SU(2) and SU(3) gauge theories when the models contain both fundamental and adjoint matter. As a result, we find that any pattern of gauge symmetry breaking can be realized by selecting an app...

INTRODUCTION The DAS28 score has now consolidated as a fundamental variable for the assessment of rheumatoid arthritis activity and is the main parameter used to establish therapeutic decisions in this disease, including the start and change of biologic therapies. OBJECTIVES We have studied the clinimetric properties of DAS28, including ceiling and floor effects and its behavior in several cl...

Atypical moles can be distinguished visually by clinical features of size greater than 6 mm in diameter, color variegation, indistinct borders, and textured surface. All patients who have atypical moles should be counselled about sun avoidance, screening of family members, and regular skin checks at least once per year. Total body photography and dermoscopy can aid in regular skin monitoring fo...