Covalent conjugation of poly(ethylene glycol) or "PEGylation" has proven an effective strategy to improve pharmaceutical protein efficacy by hindering recognition by proteases, inhibitors, and antibodies and by retarding renal clearance. Because it determines the strength and range of intermolecular steric forces and the hydrodynamic properties of the conjugates, the configuration of protein-co...

OBJECTIVES This study focuses on the adjacent venous structures of tumors and their treatment in patients with second cervical (C2) dumbbell-shaped peripheral nerve sheath tumors (PNSTs). PATIENTS AND METHODS The authors retrospectively analyzed the clinical outcome and the venous structures involved with tumors in 16 patients with C2 dumbbell-shaped PNSTs treated surgically between 2008 and ...

let $r$ be a commutative ring with identity. let $g(r)$ denote the maximal graph associated to $r$, i.e., $g(r)$ is a graph with vertices as the elements of $r$, where two distinct vertices $a$ and $b$ are adjacent if and only if there is a maximal ideal of $r$ containing both. let $gamma(r)$ denote the restriction of $g(r)$ to non-unit elements of $r$. in this paper we study the various graphi...

BACKGROUND Most spinal cavernous haemangiomas occur in the vertebral body and purely extradural cavernous hemangiomas without any vertebral body involvement is rare and account for only 4% of all extradural spinal tumors. Dumbbell-shaped spinal cavernous angioma is extremely rare, only 10 cases have been reported in the literature. CASE DESCRIPTION A 77-year-old female presented with a one-ye...

As part of an extensive radio–IR–optical–X-ray study of ROSAT clusters of galaxies in the Hydra region we have observed the bimodal Abell cluster A3528, located in the core of the Shapley Supercluster (z ≃ 0.053), with the Molonglo Observatory Synthesis Telescope at 843MHz and the Australia Telescope Compact Array at 1.4 and 2.4GHz. This is part I in a series of papers which look at the relatio...

A synthetic approach to the preparation of [2]rotaxanes (1-5·6PF(6)) incorporating bispyridinium derivatives and two 1,5-dioxynaphthalene (DNP) units situated in the rod portions of their dumbbell components that are encircled by a single cyclobis(paraquat-p-phenylene) tetracationic (CBPQT(4+)) ring has been developed. Since the π-electron-deficient bispyridinium units are introduced into the d...

In this paper, we demonstrate the stabilization of polystyrene microspheres by encapsulating them with dumbbell-shaped colloids with a sticky and a nonsticky lobe. Upon adding a depletant, an effective short ranged attraction is induced between the microspheres and the smaller, smooth lobes of the dumbbells, making those specifically sticky, whereas the interaction with the larger lobes of the ...