Chemotherapy is the standard treatment component for osteosarcoma alongside surgery. Nevertheless, survival rate of patients diagnosed with has not changed over past three decades. Phenolic compounds are widely reported having anti-proliferative effects against various cancers including osteosarcoma. Based on framework published by Arskey and O’Malley [1] this scoping review was conducted to ma...

Since the passage of 21st Century Cures Act in 2016, The US Food and Drug Administration (FDA) has applied less stringent guidelines for new drug evaluations [1], resulting a decreasing number RCTs before approval [2].

Legislative and regulatory efforts to address controlled substance diversion and overuse of narcotics are affecting prescription drug utilization and patient care. These initiatives can influence formulary drug selection, prior authorization procedures, and drug utilization strategies.

in promoting rational prescribing [4] or in clinical trials Introduction which incorporate an economic component. In some areas (e.g. Australia) economic evaluations are now formally Spending on drugs is a major target for savings in health care costs for governments around the world. Such a focus required prior to a drug being approved for reimbursement— the ‘fourth hurdle’ for a new drug afte...

Over the past two decades, drug courts have emerged as a viable alternative for addressing drug cases within the criminal justice system. In California, the Drug Court Partnership Program (DCPP) was created in 1998 and has supported and funded the development of drug courts throughout the State. This article reports on a review of California drug court evaluations through January 2000 conducted...

Adverse drug reactions are a common and important complication of drug therapy in children. Over the past decade it has become increasingly apparent that genetically controlled variations in drug disposition and response are important determinants of adverse events for many important adverse events associated with drug therapy in children. While this research has been difficult to conduct over ...

Hypertension is chronic disease with high prevalence, which can successfully be treated with antihypertensive drugs. Previous researches have shown that existing hypertension treatment guidelines are not fully implemented in practice. We have analysed antihypertensive drug utilization in Canton Sarajevo during five-year period (2004-2008). Research findings are discussed in relation to expected...

Drug utilization has been defined by the World Health Organization (WHO) as the „marketing, distribution, prescription and the use of drugs in a society, with a special emphasis on the resulting medical, social, and economic consequences“ . Drug utilization studies are usually aimed at drug use-related problem detection and quantification. These studies may be quantitative (with the objective t...

The Bureau’s occupational employment projections captured the majority of the general occupational trends over the 1984–95 period. Some of the most glaring inaccuracies in the projections for detailed occupations reflect the conservative nature of projected growth rates that was identified in previous evaluations. Although the impact of inaccurate industry employment projections on the occupati...