Background: Stimulant pharmaceuticals are abused among academic students to elevate mood, improve studying, intellectual capacity, memory and concentration, and increase wakefulness. This study was designed to evaluate the current situation of stimulant use among medical students and residents of Babol University of Medical Sciences. Methods: This cross-sectional study was conducted among 560 ...

This report is concerned with the analysis of data from “high-throughput” screening of possible drug compounds. High-throughput screening is a relatively new process yielding thousands of data points at a time, more than can be handled by traditional methods of biological data analysis. We examine a few methods for extracting knowledge from this data and also illustrate the use of descriptors f...

an alternative in vitro approach to drug screening has been the use of human cell cultures for antiviral agents and microbial cell cultures for the assessment of the carcinogenic potential of selected compounds. a number of protozoan species have been also used as drug screens for anti-protozoal agents. the ciliated protozoan tetrahymena pyriformis species has been widely utilised as a drug scr...

Screening, brief intervention, and referral to treatment (SBIRT) dissemination has been presented as a way to change medical professionals’ attitudes toward adopting prevention practices for alcohol and other drug use. We evaluated the impact of SBIRT dissemination on attitudes related to preventive practices for alcohol consumption and on the moralization of alcohol and other drug use by prima...

Phenotypic screening has regained momentum in the pharmaceutical industry owing to its success over target-based screening. Most phenotypic screening relies on nonspecific biochemical readouts regarding cellular viability, which hampers the discovery of novel drug mechanisms of action (MOAs). Here we present a Contractility-based bi-Content micro-Collagen Chip (3CChip), which establishes cellul...