Drugs of abuse dynamically regulate adult neurogenesis, which appears important for some types of learning and memory. Interestingly, a major site of adult neurogenesis, the hippocampus, is important in the formation of drug-context associations and in the mediation of drug-taking and drug-seeking behaviors in animal models of addiction. Correlative evidence suggests an inverse relationship bet...

Pharmaceutical prescribing and drug-drug interaction data underlie recommendations on drug combinations that should be avoided or closely monitored by prescribers. Because the number of patients taking multiple medications is increasing, a comprehensive view of prescribing patterns in patients is important to better assess real world pharmaceutical response and evaluate the potential for multi-...

Rats emit aversive taste reactivity (TR) behavior (i.e., gapes) following intraoral delivery of a cocaine-paired taste cue and greater conditioned aversive TR at the end of training predicts greater drug-seeking and taking. Here, we examined the development of this conditioned aversive TR behavior on a trial-by-trial basis in an effort to determine when the change in behavior occurs and whether...

INTRODUCTION Our objective was to determine the relationship between polypharmacy (treatment with prescription drugs from 6 or more drug classes concurrently) and health-related quality of life (HRQoL) among US adults with arthritis. METHODS We conducted a retrospective cohort study that used 2-year longitudinal data from the Medical Expenditure Panel Survey to analyze a cohort of 6,132 adult...

purpose: to evaluate all cases of drug induced angle closure glaucoma cases who presented to feiz hospital, isfahan during 2008-2010. case report: in this retrospective case series, we present 7 cases of drug induced angle closure glaucoma after administration of topiramate. all patients were female. the average age of patients was 33.28 years old (ranging from 19 to 44). with sufficient cornea...

Club drug use and correlates were examined among 251 Hispanic college students on the Texas-México border. Participants completed questionnaires on substance use, club drug attitudes and beliefs, sexual risk-taking behaviors, depressive symptoms, and acculturation. One-quarter of participants reported club drug use. Regression analyses demonstrated that frequency and history of lifetime use wer...

バラシクロビル（valacyclovir: VACV）は，アシクロビル（acyclovir: ACV）のプロドラッグで，小児での腎障害の報告は稀である．症例は14歳女児，帯状疱疹の診断で前医にてVACV 3,000 mg/日を処方された．内服3日後から嘔吐し，頸部痛・頭痛・背部痛を訴え，内服7日目に全身浮腫が出現した．同日，前医血液検査で腎障害を認め入院となったが，乏尿が持続し翌日当院へ転院した．VACVによる薬剤性腎障害を疑い，血中ACV除去目的に入院5日目，7日目に血液透析を実施した．入院10日目の腎生検で，糸球体・間質に炎症細胞浸潤や結晶形成は認めず，広範囲に尿細管壊死を呈しており，VACVによる中毒性腎障害を考えた．後日，内服7日目の保存血清を用い血中ACV濃度を測定すると，10.69 µg/mL（至適治療濃度：0.8–1.6 µg/mL）と異常高値であった．VACVは正常腎...