A unified synthetic strategy toward caged Garcinia natural products has been designed and implemented. Central to the strategy is a tandem Claisen/Diels-Alder/Claisen rearrangement of a suitably substituted xanthone precursor to form forbesione (1a). Serving as a template, forbesione is then used to deliver representative members of this family, including desoxygaudichaudione A (4), desoxymorel...

Many questions about the biological activity and availability of small molecules remain inaccessible to investigators who could most benefit from their answers. To narrow the gap between chemoinformatics and biology, we have developed a suite of ligand annotation, purchasability, target, and biology association tools, incorporated into ZINC and meant for investigators who are not computer speci...

BACKGROUND Drug metabolism and pharmacokinetic (DMPK) assessment has come to occupy a place of interest during the early stages of drug discovery today. Computer-based methods are slowly gaining ground in this area and are often used as initial tools to eliminate compounds likely to present uninteresting pharmacokinetic profiles and unacceptable levels of toxicity from the list of potential dru...

The question of plant layout is central in a manufacturing process. This question becomes even more important in a mass customization context, when large product diversity has to be managed. The manufacturing process, and specifically the plant layout, has to be designed taking into account this characteristic. When all products are similar, manufacturing plant layouts are relatively easy to de...

Currently experts are actively working on Russian specifications for herbal drugs, drug preparations, and medicinal products, specifically analytical procedures to evaluate the quality of these medicines. The aim this study was provide a scientific basis improving qualitative quantitative analysis preparations products containing phenolic compounds. It shown that chemical nature, physicochemica...

Plant natural products including alkaloids, polyphenols, terpenoids and flavonoids have been reported to exert anticancer activity by targeting various metabolic pathways. The biological pathways regulated plant can serve as novel drug targets. compounds or their derivatives used for cancer treatment some plant-based which are in clinical trials were discussed. Callus suspension culture with se...