background and aims. studies have shown decreased bond strength of composite resin to human and bovine bleached enamel. this study evaluated the effect of sodium ascorbate and delayed bonding on the bond strength of two adhesive systems to bleached enamel. materials and methods. the labial surfaces of 150 sound bovine incisor teeth were abraded with abrasive paper. the teeth were randomly divid...

conclusions algino-pectinate mucoadhesive formulations exhibited promising properties of a sustained release form for piroxicam and provided distinct tissue protection in stomach. objective the purpose of this research was to decrease gastric side effects of piroxicam by formulating microspheres of alginate and algino-pectinate beads of the drug. materials and methods ionotropic gelation was us...

hydrophobic grade fumed silicas are generally used in tabletting as lubricants. they are also found to retard the release of pharmaceutical actives. this is because of their hydrophobic nature, which gives good cohesive and adhesive properties. considering this point it was thought that they could be used as dry coating agents for solid dosages forms. the model drug selected for this work was p...

Ocular drug delivery is the most fascinating and challenging task faced by pharmaceutical researchers. One of the major barriers of ocular medication is to obtain and maintain a therapeutic level at the site of action for prolonged periods of time. Major problems encountered by conventional ocular dosage forms include rapid pre-corneal drug loss due to naso-lacrimal drainage; tear turnover and ...

A new monomer, 2-(methacryloyloxy)ethyl choline phosphate, and its direct polymerization into a polyvalent choline phosphate are described, providing a universal biomembrane adhesive exhibiting rapid, strong attachment to any mammalian cell membrane and fast internalization, properties of great value in applications such as tissue engineering and drug delivery.

statement of problem: recently, it has been proposed that different adhesive materials can be used for direct pulp capping. previous studies have demonstrated that multi steps dentin adhesives could form reparative dentin similar to calcium hydroxide (ch). purpose: the aim of this study was to evaluate the histological pulp response of ninety mechanically exposed cat pulps to two adhesive resin...

NIR-Responsive Nanotherapeutics In article number 2101212, Hyung Joon Cha and co-workers develop NIR-activatable tumoradhesive proteinic nanoparticles by using tunicate-inspired bioinorganic chemistry to realize effective photothermal activity with high bioavailability achieve multimodal tumor-specific therapy. The vanadium ion-doped adhesive exhibit a remarkable capability, on-demand NO gas, a...

Corneal Regeneration In article 2300192 by Lixin Xie, Qingjun Zhou, and co-workers, a photoreactive adhesive hydrogel that mimics the extracellular matrix (mainly composed of gelatin hyaluronic acid) is designed to treat large-diameter (≥6 mm) corneal defects, which effectively promotes epithelial, stromal, neural regeneration while preventing scar formation. It also holds great improvement exp...

Since last three decades delivery of the desired drug as muocoadhesive drug delivery systems has been subject of interest. Mucoadhesion involving a polymeric drug delivery system is a complex phenomenon that includes theory of diffusion, wetting, adsorption, fracture and interpenetration of polymer chains amongst various other processes. Various polymer-based properties such as the degree of cr...