Electrically triggered drug delivery represents an attractive option for actively and remotely controlling the release of a therapeutic from an implantable device (e.g., a "pharmacy-on-a-chip"). Here we report the fabrication of nanoscale thin films that can release precise quantities of a small molecule drug in response to application of a small, anodic electric potential of at least +0.5 V ve...

The drug sensing properties of procaine and berberine drug sensors based on ruthenium dioxide thin film were investigated. Ruthenium dioxide (RuO₂) membrane prepared using a sputtering method was used as substrates for the drug sensors. The procaine and berberine drug sensors were prepared using a drug-sensitive membrane that measured the procaine and berberine concentration in a linear range f...

A mucoadhesive drug delivery system for local delivery of metronidazole through vaginal route was formulated. Films were prepared by solvent evaporation method using various compositions of Carbopol, hydroxypropylmethylcellulose, chitosan, Polyox and propylene glycol. The films were evaluated for their weight, thickness, surface pH, folding endurance, mechanical, drug content uniformity, in vit...

We apply mesoporous thin silica films with nanometer-sized pores as drug carriers and incorporate the widely used anticancer drug Doxorubicin. Through single-molecule based measurements, we gain mechanistic insights into the drug diffusion inside the mesoporous film, which governs the drug-delivery at the target-site. Drug dynamics inside the nanopores is controlled by pore size and surface mod...

The aim of the present work was to formulate and evaluate transdermal films using natural polymers and to check its effectiveness for control of drug release using Ibuprofen as model drug. Study was undertaken to report the film forming properties of the natural polymers and their physicochemical data. Various drug free films with varying quantities of polymers i.e. Pectin (4, 6, 8 %), Locust b...

The use of the nanoparticle as a delivery vehicle, demonstrated by Soike and co-workers, in effect eliminates these issues; the nanoparticle surface functionality can be manipulated independently of the molecule that it contains. As a rigid and self-contained structure it can retain its integrity, and its degradation behaviour can be manipulated by the choice of degradable polymer used to encap...