in this study, microspheres containing estradiol valerate were prepared by solvent evaporation method using poly (glycolide-co-lactide) (plga 50:50) and poly (lactide). the effect of different process variables such as polymer type, drugpolymer ratio, stirring rate, volume of internal phase and temperature of external phase on the morphology, particle size distribution, encapsulation efficiency...

the present study was conducted on five healthy male cross bred calves to study the kinetic dispositionand urinary excretion of levofloxacin following its single subcutaneous administration at the dose of4 mg.kg-1. the concentration of levofloxacin in plasma and urine samples was estimated by microbiologicalassay. peak plasma level of levofloxacin (2.8 ± 0.3 μg.ml-1) was observed at 45 min and ...

due to special conditions of iran; i.e., neighboring to major centers of drug production in afghanistan during the last few decades, it was the passageway of the drug to europe. moreover, because of appropriate context of social, economic and cultural situations, there was an increased addiction and drug trafficking in iran. it is obvious that a lot of people would be involved directly and indi...

Drug efficacy strongly depends on the presence of the drug substance at the target site. As vascularization is an important factor for the distribution of drugs in tissues, we analyzed drug distribution as a function of blood vessel localization in tumor tissue. To explore distribution of the anticancer drugs afatinib, erlotinib, and sorafenib, a combined approach of matrix-assisted laser desor...

Visceral leishmaniasis is a neglected tropical disease that causes significant morbidity and mortality worldwide. Characterization of the pharmacokinetics and pharmacodynamics of antileishmanial drugs in preclinical models is important for drug development and use. Here we investigated the pharmacodynamics and drug distribution of liposomal amphotericin B (AmBisome) in Leishmania donovani-infec...

PURPOSE The present study evaluated the tissue distribution and targeting advantage of intraprostatic chemotherapy. EXPERIMENTAL DESIGN We studied the delivery and spatial distribution of a fluorescent drug, doxorubicin, in the prostate of beagle dogs, after intraprostatic or i.v. administration. Drug concentrations were measured using high-performance liquid chromatography and confocal fluor...

potassium chloride (kcl) is a highly water soluble substance which is usually used to prevent hypokalemia. oil in water disperse phase encapsulation method was used to prepare kcl loaded microcapsules using beeswax and carnauba wax as a hydrophobic matrix. the morphology and characteristics of kcl loaded microspheres were studied using scanning electron microscopy (sem), photon correlation spec...

Potassium chloride (KCl) is a highly water soluble substance which is usually used to prevent hypokalemia. Oil in water disperse phase encapsulation method was used to prepare KCl loaded microcapsules using beeswax and carnauba wax as a hydrophobic matrix. The morphology and characteristics of KCl loaded microspheres were studied using scanning electron microscopy (SEM), photon correlation spec...

  Background :Wide distribution and low half-life of acyclovir has led to a high dose consumption of the drug. Recent studies have shown that encapsulation of acyclovir in nano-carriers can increase effectiveness and decrease its side effects. We investigated the inhibitory effect of acyclovir loaded nano-niosomes against herpes simplex virus type-1 (HSV-1) in cell culture.   Methods : In-vitro...