Postherpetic neuralgia (PHN) is a chronic neuropathic pain condition that lasts 3 months or more after an outbreak of shingles. Herpes zoster, especially acute herpes associated with the reactivation inactivated varicella zoster virus in individuals who have had chickenpox. PHN persistent and often refractory pain. Patients may experience several types pain, including deep intolerable burning, ...

BACKGROUND Dose equivalence of antidepressants is critically important for clinical practice and for research. There are several methods to define and calculate dose equivalence but for antidepressants, only daily defined dose and consensus methods have been applied to date. The purpose of the present study is to examine dose equivalence of antidepressants by a less arbitrary and more systemati...

BACKGROUND Tricyclic antidepressants (TCAs) are commonly used orally for treating chronic pain states, such as neuropathic pain. TCAs produce analgesia by various mechanisms, including sodium channels, N-methyl-d-aspartate receptors, biogenic amines, opioids, inflammatory mediators, and substance P. Studies have shown that intrathecal tricyclic administration effectively attenuates pain and the...

OBJECTIVE The aim of this study is to create a rank order of the comparative efficacy and acceptability (risk of all-cause discontinuation) of antidepressant treatment in poststroke depression (PSD) by integrating direct and indirect evidence. DESIGN Multiple-treatments meta-analysis of randomised controlled trials. PARTICIPANTS Patients with depression following stroke. INTERVENTIONS 10 ...

Sintamil (2330 GO) a new dibenzoxa-zepin (Nitroxazepine hydrochloride) has been extensively studied during the last decade in animals and human beings for its antidepressant action with fairly good re-Milts (Hagadia cf ill 19f>8 and Tcja and Na-rang 197D). Some investigators (Desou/a and Chowdhary 1974 and Gupta ct.il 1976) liave been demonstrated superiority ot sin-tamil over imiprainine and t...

The inclusion process of four tricyclic antidepressant drugs (carbamazepine, imipramine, dothiepin and doxepin) with β-cyclodextrin (β-CD), as well as their possible interaction types have been investigated theoretically. The data suggest that these drugs are partially encapsulated into the β-CD cavity. The formation of the inclusion complex is predicted to be an enthalpy-driven process in gas ...

Detailed human case data is presented to illustrate the dramatic extent of the phenomenon of post-mortem drug redistribution. The data suggests that there is a post-mortem diffusion of drugs along a concentration gradient, from sites of high concentration in solid organs, into the blood with resultant artefactual elevation of drug levels in blood. Highest drug levels were found in central vesse...

We describe a procedure for determining amitriptyline and imipramine and their active metabolites nortriptyline and desipramine, respectively, at therapeutic concentrations in human plasma by use of liquid chromatography. The drugs are extracted at pH 10.5 into hexane/isoamyl alcohol, which is evaporated and the residue chromatographed. Protriptyline is used as the internal standard. As little ...