Dear Editor-in-Chief: I read and enjoyed your stylish article, "Frequency of Congenital Cardiac Malformations in Neonates with Congenital Hypothyroidism", in relation to heart disease with hypothyroidism. As we know, one of the most commonly associated congenital hypothyroidism disorders is congenital heart disease, which has a significant effect on the recovery of pat...

Objectives: The aim of this study was to evaluate the effect of “Kashi practices” on the improvement of psycho-motor skills in people with Down syndrome. Methods: In this research, 28 men with Down syndrome between 21 and 43 years of age (mean age 25.917±3.889) were randomly assigned to either a control (n=14) or an experimental group (n=14). All persons in the experimenta...

Background Down syndrome (DS) is characterized by earlier beta-amyloid (Aβ) plaque accumulation and an increased prevalence of Alzheimer’s disease (AD) due to trisomy 21 triplication the amyloid precursor protein (APP) gene. While age AD onset in DS, pathology progression non-DS populations follows similar trends DS cohort. This study compares rate Aβ between measured with [C-11]PiB at same sit...

Background: Quantitative fluorescence-polymerase chain reaction (QF-PCR) is an inexpensive and accurate method for the prenatal diagnosis of aneuploidies that applies short tandem repeats (STRs) as a chromosome-specific marker. Despite its apparent advantages, QF-PCR is not applicable in all cases due to the presence of uninformative STRs. This study was carried out to investigate the efficienc...

Purpose: This research aimed to study the effect of 8 weeks core stability training on static balance of the children with Down syndrome. Methods: A total of 16 children with Down syndrome from rehabilitation center of Noor Abad City were selected and randomly divided into 2 groups of control (n=8) and experimental (n=8). At the pretest and posttest, subjects’ static balan...

the aim of this research was to determine the effect of selective exercise training on reducing the symptom of hypotonia and changing body composition in down syndrome adults. the research was performed in nemoneh disability rehabilitation centre of tehran. 24 men with down syndrome (mean age 26.185± 3.933) were randomly assigned to either a control (n=11) or an experimental group (n=13). the e...

Down syndrome (DS) is a birth defect with huge medical and social costs, caused by trisomy of whole or part of chromosome 21. It is the most prevalent genetic disease worldwide and the common genetic cause of intellectual disabilities appearing in about 1 in 400-1500 newborns. Although the syndrome had been described thousands of years before, it was named after John Langdon Down who described ...