BACKGROUND Low iodine diet (LID) is recommended in patients with differentiated thyroid cancer before radioiodine administration. Patients with increased thyroglobulin (Tg) level, but negative (131)I whole body scan present diagnostic and therapeutic dilemma. This study was designed to evaluate the benefit of a two-week LID in patients with elevated serum Tg levels and negative (131)I whole bod...

Diversity and complexity of MDM2 mechanisms govern its principal function as the cellular antagonist of the p53 tumor suppressor. Structural and biophysical studies have demonstrated that MDM2 binding could be regulated by the dynamics of a pseudo-substrate lid motif. However, these experiments and subsequent computational studies have produced conflicting mechanistic models of MDM2 function an...

Pure acoustic neural models, particularly the LSTM-RNN model, have shown great potential in language identification (LID). However, the phonetic information has been largely overlooked by most of existing neural LID models, although this information has been used in the conventional phonetic LID systems with a great success. We present a phone-aware neural LID architecture, which is a deep LSTM...

This paper deals with the design and implementation of cross-platform, D2Q9-BGK D3Q27-MRT, lattice Boltzmann method solver for 2D 3D flows developed ArrayFire library high-performance computing. The leverages ArrayFire’s just-in-time compilation engine compiling high-level code into optimized kernels both CUDA OpenCL GPU backends. We also provide C++ Rust implementations show that it is possibl...

Levodopa is the most effective therapy for the motor deficits of Parkinson's disease (PD), but long term treatment leads to the development of L-DOPA-induced dyskinesia (LID). Our previous studies indicate enhanced excitability of striatal cholinergic interneurons (ChIs) in mice expressing LID and reduction of LID when ChIs are selectively ablated. Recent gene expression analysis indicates that...

During prophase of the first meiotic division (prophase I), chromatin dynamically reorganises to recombine and prepare for chromosome segregation. Histone modifying enzymes are major regulators of chromatin structure, but our knowledge of their roles in prophase I is still limited. Here we report on crucial roles of Kdm5/Lid, one of two histone demethylases in Drosophila that remove one of the ...

Degeneration of dopaminergic neurons causes Parkinson's disease. Dopamine replacement therapy with L-DOPA is the best available treatment. However, patients develop L-DOPA-induced dyskinesia (LID). In the hemiparkinsonian rat, chronic L-DOPA increases rotations and abnormal involuntary movements modeling LID, via supersensitive dopamine receptors. Dopamine receptors are controlled by G protein-...

double-diffusive mixed convection in a lid-driven square enclosure filled with al2o3-water is numerically investigated. two-dimensional nonlinear governing equations are discretized using the control volume method and hybrid scheme. the equations are solved using simpler algorithm. the results are displayed in the form of streamlines, isotherms, and iso-concentrations when the richardson number...