Although different lesion and neuroimaging studies had highlighted the importance of the dorsolateral prefrontal cortex (DLPFC) in language switching, the nature of this higher cortical disorder of communication and its neural correlates have not been clearly established. To further investigate the functional involvement of the DLPFC, we used transcranial magnetic stimulation (TMS) given as the...

Prefrontal cortex (PFC) supports flexible behavior by mediating cognitive control, though the elemental forms of control supported by PFC remain a central debate. Dorsolateral PFC (DLPFC) is thought to guide response selection under conditions of response conflict or, alternatively, may refresh recently active representations within working memory. Lateral frontopolar cortex (FPC) may also adju...

The conflict-monitoring hypothesis posits that anterior cingulate cortex (ACC) monitors conflict in information processing and recruits dorsolateral prefrontal cortex (DLPFC) to resolve competition as needed. We used fMRI to test this prediction directly in the context of a task-switching paradigm, in which subjects responded to the color or the motion of a visual stimulus. Conflict was indexed...

BACKGROUND Several lines of evidence suggest that dysfunction of the dorsolateral prefrontal cortex (DLPFC) and orbitofrontal cortex (OFC) contributes to the pathophysiology of pervasive developmental disorders (PDD). The purpose of this study was to investigate neuropsychological dysfunctions in both the DLPFC and OFC of children and adolescents with high-functioning PDD. METHODS The Iowa ga...

Background and objective: Drug craving is considered to be a major problem in addiction treatment. Neuroimaging research has revealed various areas for drug craving, among which two key areas are the dorsolateral prefrontal cortex (DLPFC) and the cerebellum. The DLPFC is involved in different cognitive tasks like the inhibitory control over seductive options harboring the promise of immediate r...

Background Alzheimer’s Dementia (AD) is characterized by cognitive and neuropsychiatric symptoms (NPS). Recently, decline in AD has been linked to increased cortical excitability. However, the relationship between NPS excitability remains unclear. This study investigated dorsolateral prefrontal cortex (DLPFC). Method 24 participants with probable diagnosed using National Institute of Aging-Alzh...

Research suggests that the combination of different non-invasive brain stimulation techniques, such as intermittent theta-burst (iTBS) and transcranial direct current (tDCS), could enhance effects stimulation. Studies investigating tDCS iTBS over dorsolateral prefrontal cortex (DLPFC) are lacking. In this within-subjects study, we evaluated additive with on psychophysiological measures stress. ...

Transcranial magnetic stimulation is investigated as a new tool in the therapy of depression and other psychiatric disorders. In almost all studies, the dorsolateral prefrontal cortex (DLPFC) has been selected as the target site for stimulation. Usually this region was determined by identifying the patient's motor cortex, and from there the coil was placed 5 cm rostrally. The aim of our study w...

A new fMRI study by Heekeren and colleagues suggests that left dorsolateral prefrontal cortex (DLPFC) contains a region that integrates sensory evidence supporting perceptual decisions. DLPFC meets two criteria posited by Heekeren et al. for such a region: (1) its activity is correlated in time with the output of sensory areas of the visual cortex measured simultaneously, and (2) as expected of...

It is suggested that, rather than Broca's area playing its role in syntactic comprehension because its functions are a specialization those of the dorsolateral prefrontal cortex (DLPFC) or derived from sensori-motor functions of cortex from which it is evolutionarily descended, this region may be involved in this aspect of language because of its intrinsic neural organization.