NetKuang is an extension to Baldwin's SU-Kuang. It runs on networks of computers using Unix and can nd vulnerabilities created by poor system conngu-ration. Vulnerabilities are discovered using a backwards goal-based search that is breadth-rst on individual hosts and parallel when multiple hosts are checked. An implementation in C++ found real vul-nerabilities on production systems. Tests show ...

The operational rating system in building energy performance certificates (EPCs) has been used for systematically monitoring and diagnosing the energy performance in the operation and maintenance phases of existing buildings. However, there are several limitations of the conventional operational rating system, which can be subdivided into three aspects: (i) building category; (ii) region catego...

Mu opioid receptor (MOR) agonists are widely used for the treatment of pain; however, chronic use results in the development of tolerance and dependence. It has been demonstrated that coadministration of a MOR agonist with a delta opioid receptor (DOR) antagonist maintains the analgesia associated with MOR agonists, but with reduced negative side-effects. Using our newly refined opioid receptor...

INTRODUCTION Two types of partial wrap are commonly performed in achalasia patients after Heller myotomy: the posterior 270° fundoplication (Toupet) and the anterior 180° fundoplication (Dor). The optimal type of fundoplication (posterior vs. anterior) is still debated. AIM To compare the long-term rates of dysphagia, reflux symptoms and patient satisfaction with current postoperative conditi...

We report the discovery of 19 variable stars and two blue–stragglers in the field of the open cluster NGC 6866. Three of the variable stars we classify as δ Sct, two, as γ Dor, four, as W UMa, two, as ellipsoidal variables, and one, as an eclipsing binary. Seven stars show irregular variability. Two of the pulsators, a δ Sct star NGC 6866-29 and a γ Dor star NGC 6866-21, are multiperiodic. From...

Ubiquitination of cytoplasmic lysine residues can target G protein-coupled receptors (GPCRs) to proteasomes and has recently been shown to also be required for sorting of certain GPCRs to lysosomes following ligand-induced endocytosis. We addressed the generality of this mechanism by examining regulated proteolysis of the murine delta opioid receptor (DOR) expressed in human embryonic kidney 29...

The pathological changes of Parkinson's disease (PD) are, at least partially, associated with the dysregulation of PTEN-induced putative kinase 1 (PINK1) and caspase 3. Since hypoxic and neurotoxic insults are underlying causes of PD, and since δ-opioid receptor (DOR) is neuroprotective against hypoxic/ischemic insults, we sought to determine whether DOR activation could protect the cells from ...

Agonist-induced receptor phosphorylation is an initial step in opioid receptor desensitization, a molecular mechanism of opioid tolerance and dependence. Our previous research suggested that agonist-induced d-opioid receptor (DOR) phosphorylation occurs at the receptor carboxyl terminal domain. The current study was carried out to identify the site of DOR phosphorylation during agonist stimulat...

JUSTIFICATIVA E OBJETIVOS: A associação de baixas doses de morfina subaracnóidea e diclofenaco por via muscular tem se mostrado eficaz para o controle da dor pós-operatória em pacientes submetidas à cesariana sob raquianestesia. O cetoprofeno pode ser vantajoso em relação ao diclofenaco, já que sua administração pode ser realizada por via venosa. O objetivo do estudo foi comparar a eficácia ana...

A dor pélvica crônica (DPC) na mulher é uma condição comum e debilitante, com etiologia complexa, usualmente resultante da interação de vários sistemas – gastrointestinal, urinário, ginecológico, músculo-esquelético, neurológico e endocrinológico, influenciado ainda por fatores socioculturais e psicológicos. Permanece pouco compreendida, gera ansiedade, além de extensivas e repetidas investigaç...