Monoaminergic neurotransmitter dopamine plays a critical role in various vital functions including hormonal regulation, reward, emotions and food intake. Multiple aspects of food intake that include food selection, satiety and energy expenditure could be modulated by changes in central dopaminergic transmission (1,2). Several lines of research indicate that abnormal dopaminergic neurotransmissi...

In the "virtual work model," left ventricular total mechanical energy (TME) is linearly related to myocardial oxygen consumption (MV˙o 2). This relationship (MV˙o 2-TME) is supposedly independent of inotropic stimulation, vascular loading, and heart rate variations. We reexamined the effect of inotropic stimulation (dopamine) on the metabolic to mechanical energy transfer in nine open-chest ane...

Antipsychotic drugs are the mainstay pharmacotherapy for schizophrenia and related psychiatric disorders. While the metabolic pathways of antipsychotic drugs have been well defined, the role of drug transporters in the disposition and effects of antipsychotic drugs has not been systematically explored. P-glycoprotein has ubiquitous expression in brain endothelial cells and plays a protective ro...

Dopaminergic denervation supersensitivity has been implicated in the pathogenesis of levodopa-induced dyskinesias, the most common and limiting side effect in the drug treatment of Parkinson's disease, yet the mechanisms that mediate altered drug sensitivity remain poorly understood. In animals models, one key component of denervation supersensitivity is the enhanced efficacy of selective D1 ag...

Many studies have shown that the pollutant simazine (6-chloro-N,N'-diethyl-1,3,5-triazine-2,4-diamine), which has been overused, inhibits the proliferation of mammalian dopaminergic cells, and affects the developmental differentiation of mammalian dopaminergic neurons. However, few studies have shown the effects of simazine on dopaminergic metabolism in these cells. Therefore, we aim to examine...

Pathophysiological processes that underlie the profound neuropsychiatric disturbances in schizophrenia are poorly understood. However, the clinical course of the disease, and a number of clinical and basic science observations, provide direction for formulating pathophysiological models that could be empirically tested. For example, repeated psychostimulant administration to healthy subjects ca...

After Alzheimer's disease, Parkinson's disease is the most common nerve-damaging disease. Parkinson's is a progressive and chronic disease where cells secrete dopamine-cut black flesh and in the absence of dopamine in the brain destroyed the irregular body movements. Man eats the food that causes the formation of the neurotransmitters. Tthree neurotransmitters: dopamine, serotonin, norepinephri...

We report the polymerization of dopamine analogue 4-(2-azidoethyl)benzene-1,2-diol (dopamine azide), where amine group is switched to azide, resulting in particles stable water but, contrast other polycatechol based polymers, soluble organic solvents.

Norcoclaurine synthase (NCS) (EC 4.2.1.78) catalyzes the Pictet-Spengler condensation of dopamine and an aldehyde, forming a substituted (S)-tetrahydroisoquinoline, a pharmaceutically important moiety. This unique activity has led to NCS being used for both in vitro biocatalysis and in vivo recombinant metabolism. Future engineering of NCS activity to enable the synthesis of diverse tetrahydroi...