The impact and consequences of damage generation into genomic DNA, especially in the form of DNA double-strand breaks (DSB), and of the DNA damage response (DDR) pathways that are promptly activated have been elucidated in great detail 1-2. Most of this research, however, has been performed on proliferating, often cancerous, cell lines. In a mammalian body, the majority of cells is terminally d...

The various symptoms associated with hereditary defects in the DNA damage response (DDR), which range from developmental and neurological abnormalities and immunodeficiency to tissue-specific cancers and accelerated aging, suggest that DNA damage affects tissues differently. Mechanistic DDR studies are, however, mostly performed in vitro, in unicellular model systems or cultured cells, precludi...

Dietary restriction (DR) extends lifespan in man species and modulates evolutionary conserved signalling and metabolic pathways. Most of these studies were done in adult animals. Here we investigated fat phenotypes of C. elegans larvae and adults which were exposed to DR during development. This approach was named "developmental-DR" (dDR). Moderate as well as stringent dDR increased the triglyc...

1 Aspetar – Qatar Orthopaedic and Sports Medicine Hospital, Athlete Health and Performance Research Centre, Doha, Qatar, 2 Endurance Research Group, School of Sport and Exercise Sciences, University of Kent, Chatham Maritime, Chatham, United Kingdom, 3 Aspetar – Qatar Orthopaedic and Sports Medicine Hospital, Exercise and Sports Science Department, Doha, Qatar, 4 Aspetar – Qatar Orthopaedic and...

Asia Pacific Economic Cooperation (APEC) forum launched a process that could ultimately produce the largest single act of trade liberalization in history. They agreed to " seriously consider " negotiating a Free Trade Area of the Asia Pacific (FTAAP) and instructed their officials to " undertake further studies on ways and means to promote " the initiative so that they could address it at their...