Welcome to the first edition of our new Object Interconnections column concerning distributed object computing (DOC) and C++. In this column, we will explore a wide range of topics related to DOC. Our goal is to de-mystify the terminology and dispel the hype surrounding DOC. In place of hype, we will focus on object-oriented principles, methods, and tools that are emerging to support DOC using ...

PURPOSE A lipid-based, nanomicelle-loaded docetaxel (M-DOC) was designed and characterized. Optical imaging was employed to evaluate the pharmacokinetics and antitumor efficacy of docetaxel in vivo. MATERIALS AND METHODS The M-DOC was prepared using the emulsion-diffusion method. Transmission electron microscopy and dynamic light scattering were used to assess the morphology and particle size...

Stream water dissolved organic carbon (DOC) correlates positively with soil organic carbon (SOC) in many biomes. Does this relationship hold in a small geographic region when variations of temperature, precipitation and vegetation are driven by a significant altitudinal gradient? We examined the spatial connectivity between concentrations of DOC in headwater stream and contents of riparian SOC ...

The Doc toxin from bacteriophage P1 (of the phd-doc toxin-antitoxin system) has served as a model for the family of Doc toxins, many of which are harbored in the genomes of pathogens. We have shown previously that the mode of action of this toxin is distinct from the majority derived from toxin-antitoxin systems: it does not cleave RNA; in fact P1 Doc expression leads to mRNA stabilization. How...

The global ocean contains amassive reservoir (662±32PgC) of dissolved organic carbon (DOC), and its dynamics, particularly in the deepest zones, are only slowly being understood. DOC in the deep ocean is ubiquitously low in concentration (~35 to 48μmol kg ) and aged (4000 to 6000years), persisting for multiple meridional overturning circulations. Deep waters relatively enriched in DOC form in t...

1. Dissolved organic carbon (DOC) plays a central role in the dynamics of stream and river ecosystems, affecting processes such as metabolism, the balance between autotrophy and heterotrophy, acidity, nutrient uptake and bioavailability of toxic compounds. However, despite its importance to stream processes, restoration and management activities rarely incorporate DOC as a major management crit...

Nanoscale drug carriers have been extensively developed to improve drug therapeutic efficiency. However, delivery of chemotherapeutic agents to tumor tissues and cells has not been favorably managed. In this study, we developed a novel "intelligent" nanoparticle, consisting of a gelatinase-cleavage peptide with poly(ethylene glycol) (PEG) and poly(ɛ-caprolactone) (PCL)-based structure for tumor...