����� ��������� �� ��� ���� ������ ���� �� ��� ���matory and immune disease, and the prevalence and incidence of gout increases annually. Genetic variations in the DNA methyltransferases (DNMTs) gene have not, to the best of our k��wl�dg�, b��� �������d �� �������� g��� �x�������� ��d �� participate in the pathogenesis of gout. The aim of the present study was to investigate whether the DNMT1, ...

BACKGROUND Increasing studies showed that abnormal changes in single nucleotide polymorphisms (SNPs) of DNMTs (DNMT1, DNMT3A and DNMT3B) were associated with occurrence or decrease of various tumors. However, the associations between DNMTs variations and gastric cancer (GC) risk were still conflicting. We aimed to assess the effect of DNMTs polymorphisms on the susceptibility to GC. METHODS F...

The genome contains genetic and epigenetic information. While the genome provides the blueprint for the manufacture of all the proteins required to create a living thing, the epigenetic information provides instruction on how, where, and when the genetic information should be used (Robertson, 2001). The major form of epigenetic information in mammalian cells is DNA methylation that is the coval...

Promoter methylation is one of the main epigenetic mechanisms that lead to the inactivation of tumor suppressor genes during carcinogenesis. Due to the reversible nature of DNA methylation, many studies have been performed to correct theses epigenetic defects by inhibiting DNA methyltransferases (DNMTs). In this case novel therapeutics especially siRNA oligonucleotides have been used to specifi...

Background: Decitabine (5-aza-2'-deoxycytidine, DAC) is a deoxycytidine analog currently used as an effective drug against myelodysplastic syndromes and acute myeloid leukemia. Although various studies have pointed out the epigenetic effects of this drug, its epigenetic mechanisms in different leukemic cell lines are not specified. In this lab trial study, possible epigenetic effects of decitab...

Promoter methylation is one of the main epigenetic mechanisms that lead to the inactivation of tumor suppressor genes during carcinogenesis. Due to the reversible nature of DNA methylation, many studies have been performed to correct theses epigenetic defects by inhibiting DNA methyltransferases (DNMTs). In this case novel therapeutics especially siRNA oligonucleotides have been used to specifi...

DNA methylation is a chromatin modification that plays an important role in the epigenetic regulation of gene expression. Changes patterns are characteristic many malignant neoplasms. occurred by methyltransferases (DNMTs), while demethylation mediated TET family proteins. Mutations and changes expression profile these enzymes lead to hypo- hypermethylation have strong impact on carcinogenesis....