نتایج جستجو برای: dna mitochondrial

تعداد نتایج: 613263  

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2007
Suhail K Mithani Ian M Smith Shaoyu Zhou Andrew Gray Wayne M Koch Anirban Maitra Joseph A Califano

PURPOSE Alterations of the mitochondrial genome have been identified in multiple solid tumors and in many head and neck squamous cell carcinomas (HNSCC). Identification of mitochondrial mutations in the salivary rinses of patients with HNSCC has potential application in disease detection. In this study, we used the MitoChip v2.0 mitochondrial genome resequencing array to detect minor population...

2007
Cenk Aral Ayşe Özer

Mitochondrial DNA has been proposed to be involved in carcinogenesis because of high susceptibility to mutations and limited repair mechanisms in comparison to nuclear DNA. In this paper, we review mitochondrial genome instability, relation of mitochondrial DNA mutations with apoptosis and mitochondrial genomic aberrations reported in solid tumors of the thyroid, colorectal, breast, and gastric

Journal: :Genetics and molecular research : GMR 2015
L V F Pessôa F F Bressan M R Chiaratti P R L Pires F Perecin L C Smith F V Meirelles

Large number of cellular changes and diseases are related to mutations in the mitochondrial DNA copy number. Cell culture in the presence of ethidium bromide is a known way of depleting mitochondrial DNA and is a useful model for studying such conditions. Interestingly, the morphology of these depleted cells resembles that of pluripotent cells, as they present larger and fragmented mitochondria...

Journal: :genetics in the 3rd millennium 0
محمد مهدی بانویی mohammad mehdi banoei national institute for genetic engineering and biotechnology, tehran, iran مسعود هوشمند massoud houshmand national institute for genetic engineering and biotechnology, tehran, iran مهدی شریعت پناهی mehdi shafa shariatpanahi national institute for genetic engineering and biotechnology, tehran, iran پروین شریعتی parvin shariati national institute for genetic engineering and biotechnology, tehran, iran مریم رستمی maryam rostami national institute for genetic engineering and biotechnology, tehran, iran معصومه دهقان منشدی masoumeh dehghan manshadi national institute for genetic engineering and biotechnology, tehran, iran طیبه مجیدی زاده

the mitochondrial dna (mtdna) may play an essential role in the pathogenesis of the respiratory chain complex activities in neurodegenerative disorders such as huntington’s disease (hd). research studies have been conducted to determine the possible levels of mitochondrial defect (deletion) in hd patients and the interaction between the expanded huntingtin gene as a nuclear gene and mitochondri...

Journal: :Environmental and molecular mutagenesis 2004
Janice A Nicklas Elice M Brooks Timothy C Hunter Richard Single Richard F Branda

Changes in mitochondrial DNA copy number and increases in mitochondrial DNA mutations, especially deletions, have been associated with exposure to mutagens and with aging. Common deletions that are the result of recombination between direct repeats in human and rat (4,977 and 4,834, bp, respectively) are known to increase in tissues of aged individuals. Previous studies have used long-distance ...

Journal: :The Journal of biological chemistry 1969
N J Gross G S Getz M Rabinowitz

The apparent turnovers of mitochondrial DNA and of the phospholipids, cardiolipln, lecithin, and phosphatidyl ethanolamine, have been determined simultaneously in the mitochondria of rat liver, kidney, brain, and heart. The turnover rate of mitochondrial DNA in liver was similar to previously reported turnover rates of other mitochondrial components. Mitochondrial DNA has a half-life of 6.7 day...

Journal: :Genome research 2015
Young Seok Ju Jose M C Tubio William Mifsud Beiyuan Fu Helen R Davies Manasa Ramakrishna Yilong Li Lucy Yates Gunes Gundem Patrick S Tarpey Sam Behjati Elli Papaemmanuil Sancha Martin Anthony Fullam Moritz Gerstung Jyoti Nangalia Anthony R Green Carlos Caldas Åke Borg Andrew Tutt Ming Ta Michael Lee Laura J van't Veer Benita K T Tan Samuel Aparicio Paul N Span John W M Martens Stian Knappskog Anne Vincent-Salomon Anne-Lise Børresen-Dale Jórunn Erla Eyfjörd Ola Myklebost Adrienne M Flanagan Christopher Foster David E Neal Colin Cooper Rosalind Eeles Steven G Bova Sunil R Lakhani Christine Desmedt Gilles Thomas Andrea L Richardson Colin A Purdie Alastair M Thompson Ultan McDermott Fengtang Yang Serena Nik-Zainal Peter J Campbell Michael R Stratton

Mitochondrial genomes are separated from the nuclear genome for most of the cell cycle by the nuclear double membrane, intervening cytoplasm, and the mitochondrial double membrane. Despite these physical barriers, we show that somatically acquired mitochondrial-nuclear genome fusion sequences are present in cancer cells. Most occur in conjunction with intranuclear genomic rearrangements, and th...

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