Chemical modifications of innate DNA/RNA aptamers facilitate the improvement their function. Herein, we report our modular strategy to manipulate a thrombin-binding DNA aptamer (TBA) improve its anticoagulation activity and binding affinity. A set amino acid conjugates, termed acid–nucleic hybrids or ANHs, was synthesized incorporated into TBA loop sequences. We found that substitutions with hy...

Threading intercalators are a novel class of materials that carry two substituents along the diagonal positions an aromatic ring. When bound to DNA, these project out in DNA grooves. Tetranuclear complexes appear be promising threading for developing therapeutics against cancer and viral infections require high nucleic acid binding affinity. The objective this work was prepare thiosemicarbazone...

The aim of this work is to present the experimental results in form an algorithm for analyzing modification screen printed electrodes, including possibility its regeneration irreversibly oxidizing biologically active compounds (drugs, DNA and proteins). A protocol was developed quantitative analysis study mechanism drug-DNA interaction by differential pulse voltammetry, following parameters: co...

Dithiocarbamates, with their high lipophilic character and good chelating properties, could provide stabile transition metal complexes enable these metal-based drugs to reach biological targets. Palladium(II) gold(III) complexes, due its structural similarity platinum(II)compounds, be competitive candidates for implementing developing new pharmacological agents. Herein, novel complex triammoniu...

BI-3802 is a relatively new anticancer drug known to bind the transcription repressor BCL6 and potently kill most common form of cancer cells, B-cell lymphoma, found in lymphatic system. Based on its structure we believe this small molecule can DNA through intercalation. We use Optical tweezers trap single explore binding with DNA. Once molecule, stretch measure tension as function extension.

The study of the interaction between DNA and small molecules such as drugs is one of the current general interest and importance. In this paper, the electrochemical investigation of the interaction between some flavonoids such as rutin, quercetin, and hesperidin with dsDNA on the surface of Supramolecular Ionic Liquid grafted on the Graphene Oxide Modified Glassy Carbon Electrode (</s...