abstractferulago angulata boiss. known in iran as chavir, has some bioactive compounds having antioxidant activity. because of its antioxidant activities, it sounded chavir extract can be a good candidate for finding chemopreventive agents having inductive apoptosis properties on cancer cells. in this study, the cytotoxic effects and proapoptotic activities of chavir’s leaf and flower extracts ...

objective(s):one cause of cigarette smoking is oxidative stress that may alter the cellular antioxidant defense system, induce apoptosis in lung tissue, inflammation and damage in liver, lung, and kidney. it has been shown that chinese green tea (cgt) (lung chen tea) has higher antioxidant property than black tea. in this paper, we will explore the preventive effect of cgt on cigarette smoke-in...

background: microtubules (mt) are important components of cell cytoskeleton and play key roles in cell motility mitosis and meiosis. they are also the targets of several anticancer agents which indicating their importance in maintaining cell viability. microtubular reorganization contributing to apoptotic morphology occurs in normal and neoplastic cells undergoing apoptosis induced by cytotoxic...

background: breast cancer is the most common diagnosed cancer among women in the world. snail1 plays a role in the development of the invasive phenotypes of cancer, neural cell differentiation, cell division and apoptosis in tumor cells. traces of snail1 in metastasis of breast cancer to bone are observed. the aim of this study was to investigate the effect of specific snail1 sirnas on the prol...

Neutrophils detect bacterial constituents, including bacterial DNA (CpG DNA), which elicits innate immunity and prolongs the functional life span of neutrophils through suppression of apoptosis. Both the anti-apoptotic protein Mcl-1 and activation of NF-κB have been implicated in neutrophil survival, but there is no evidence that these are linked in neutrophils. We hypothesized that CpG DNA cou...

BACKGROUND Excessive autoantibody production characterizing systemic lupus erythematosus (SLE) occurs irrespective of the disease's clinical status and is linked to increased lymphocyte apoptosis. Herein, we tested the hypothesis that defective DNA damage repair contributes to increased apoptosis in SLE. METHODS We evaluated nucleotide excision repair at the N-ras locus, DNA double-strand bre...

Most solid tumors contain hypoxic and nutrient-deprived microenvironments. The cancer cells in these microenvironments have been reported to exhibit radioresistance. We previously that nutrient starvation increases the expression and/or activity of ATM DNA-PKcs, which are involved repair DNA double-strand breaks induced by ionizing radiation. In present study, elucidate molecular mechanisms und...

Tip60 is a multifunctional acetyltransferase involved in multiple cellular functions. Acetylation of p53 at K120 by Tip60 promotes p53-mediated apoptosis after DNA damage. We previous showed that Tip60 activity is induced by phosphorylation at T158 by p38. In this study, we investigated the role of p38-mediated Tip60 phosphorylation in p53-mediated, DNA damage-induced apoptosis. We found that D...

Background and Aims: Recent studies have shown the anticancer properties of metformin, which is widely used in diabetes mellitus. The possible mechanisms effects metformin not been fully elucidated. We aimed to investigate cytotoxic, genotoxic, apoptotic HepG2 HeLa cells. Methods: cytotoxicity, genotoxicity, apoptotoic were determined by MTT method, Comet assay, FACS respectively. Results: Met...

Hepatotoxicity of antipsychotic drugs remains an urgent problem modern medicine. Therefore, the purpose study was to investigate nuclear DNA content and cell cycle phases rat liver cells under Сhlorpromazine administration at doses ranging from 3.5 mg/kg 28 for 30 60 days. The conducted on sexually mature female rats. Chlorpromazine administered once daily days mg/kg, 7 14 21 mg/kg. in nuclei d...