Este trabajo analiza de forma crítica la Responsabilidad Ampliada del Productor (RAP) como instrumento para lograr una efectiva economía circular. Con este fin, se estudia su conceptualización, regulación y evolución. requiere revisión constante minimización los residuos, apostando por prevención, especialmente durabilidad productos. En primer lugar, configuración inicial en Directiva (UE) 2008...

Paternally expressed Insulin-like Growth Factor II (IGF2) encodes a gene whose protein product functions as a potent growth mitogen. Overexpression of IGF2 has been implicated in a wide number of disorders and diseases. IGF2 is regulated in part by differential methylation of the two parentally derived alleles. The differentially methylated region (DMR) located upstream of the imprinted promote...

GPR120 is a long-chain fatty acid receptor that stimulates incretin hormone release from colonic endocrine cells and is implicated in macrophage and adipocyte function. The functional consequences of long (L) and short (S) human GPR120 splice variants, which differ by insertion of 16 amino acids in the third intracellular loop, are currently unknown. Here we compare signaling and intracellular ...

Using three-dimensional (3D) transesophageal echocardiography (TEE) and isometric handgrip exercise (IHE), we investigated the determinants of exercise-induced mitral regurgitation (MR) according to MR etiologies. Seventy-six patients with more than moderate MR, 40 functional (FMR) 36 degenerative (DMR), underwent 3D TEE combined IHE. Mitral valve (MV) geometry vena contracta area (3D VCA) were...

High-resolution dive depth and acceleration recordings from nearshore (Sarasota Bay, < 30 m), offshore (Bermuda) bottlenose dolphins (Tursiops spp.) were used to estimate the diving metabolic rate (DMR) locomotor (LMR, L O2/min) during three phases of (descent, bottom, ascent). For shallow dives (depth ≤ we found no differences between two ecotypes in LMR diving, nor postdive interval dives. in...

A radio communication system (RCS) based on digital trunking of the mobile (DMR) type Tier-III with any brands is installed, consisting devices, portable repeater devices antenna, and power supply device. The technical specifications for these types equipment have been approved by institution-owned. This paper describes a infrastructure RCS predicting area coverage independent or private use. r...

OBJECTIVE To assess procedural safety and glycemic indices at 6 months in a first-in-human study of duodenal mucosal resurfacing (DMR), a novel, minimally invasive, upper endoscopic procedure involving hydrothermal ablation of the duodenal mucosa, in patients with type 2 diabetes and HbA1c ≥7.5% (58 mmol/mol) on one or more oral antidiabetic agents. RESEARCH DESIGN AND METHODS Using novel bal...

Epigenetic variation may significantly contribute to the risk of common disease. Currently, little is known about the extent and causes of epigenetic variation. Here, we investigated the contribution of heritable influences and the combined effect of environmental and stochastic factors to variation in DNA methylation of the IGF2/H19 locus. Moreover, we tested whether this locus was subject to ...