OBJECTIVE To determine Patient Satisfaction of DMPA-SC (104 mg/0.65 mL) injected subcutaneously once every 3 months. METHODS It was a Descriptive case series with the centre in Rawalpindi (Holy Family Hospital, Gynecology and Obstetrics Unit), Pakistan. Twenty five patients were selected by purposive sampling and followed up in Rawalpindi center (Holy Family Hospital, Gynaecology and Obstetri...

The DmpA (d-aminopeptidase A) protein produced by Ochrobactrum anthropi hydrolyses p-nitroanilide derivatives of glycine and d-alanine more efficiently than that of l-alanine. When regular peptides are utilized as substrates, the enzyme behaves as an aminopeptidase with a preference for N-terminal residues in an l configuration, thus exemplifying an interesting case of stereospecificity reversa...

Progestin-only contraceptives are associated with menstrual bleeding disturbances; a major reason why these agents are discontinued. The pathogenesis of abnormal uterine bleeding associated with progestin-only contraceptives remains ill-defined. Matrix metalloproteinases (MMPs) and leukocytes are postulated to be involved in the process of normal menstruation. Immunolocalization of MMPs and leu...

Background In 2004, WHO Pharmaceuticals Newsletter reported a Pfizer Canada advice originated by results of new clinical studies that suggest the association between use of medroxyprogesterone acetate suspension for injection and substantial loss in bone mineral density. The publication stressed: “The loss in bone density is greater with increasing duration of treatment. The loss in bone densit...

background: the main cause of discontinuing the use of depomedroxy progesterone acetate (dmpa) is irregular bleeding. this study compared placebo with two kinds of combined oral contraceptive pills including low dose (ldocp) and high dose (hdocp) on control of abnormal uterine bleeding in dmpa users. methods: ninety dmpa users complaining of bleeding were studied in a triple blind randomized cl...

Family Planning Perspectives In the early 1990s, the U.S. Food and Drug Administration approved subdermal contraceptive implants and the injectable contraceptive depot medroxy progesterone acetate (DMPA), adding two long-term methods to the array of contraceptives currently available. A primary concern associated with these highly effective methods is that, as has been documented among women wh...

Aqueous polyurethane emulsion was prepared with diphenylmethane diisocyanate (MDI), polybutylene adipate diol (PBA-1000) as main raw materials and 2, 2-dihydroxymethyl propionic acid (DMPA) hydrophilic chain extender. On this basis, epoxy resin E-44 introduced to modify the prepolymer, modified waterborne obtained. In order obtain better performance polyurethane, effect of DMPA content、the amou...

The association between contraceptive use and breast-feeding duration was investigated in 2380 women in rural Bangladesh where women usually stop breast-feeding once pregnant. Life table analysis showed that women receiving regular injections of depo medroxy progesterone acetate (DMPA) and those using non-hormonal contraception breast-fed significantly longer than women using no contraception. ...