The objective of this study was to evaluate the toxicokinetics and metabolism of pseudocumene after inhalation exposure. Male Wistar rats were exposed to pseudocumene vapors at nominal concentrations of 25,100 or 250 ppm in the dynamic inhalation chambers for 6 h. Blood samples were collected during (between 1st and 6th h) and after exposure (betwen 6th min and 6th h). Blood concentrations of p...

a!. (13) treated Sprague-Dawley rats of various ages with a single dose of 3-methybcholanthrene and reported that rats between 50 and 65 days of age were most susceptible to tumorigenesis. Similar results were obtained by Dao (7) with DMBA2 in Wistar-Furth rats. The tumor incidence varied from 80% in rats given DMBA at 50 days of age to less than 5% in rats given DMBA at 150 days of age. There ...

Polycyclic aromatic hydrocarbons (PAH) are procarcinogens that can be commonly found in our food and environment. Upon biotransformation in our body system, they can cause DNA damage through the generation of genotoxic species and oxidative stress. Phase I and II enzymes are pivotal in the process of proximate carcinogen formation and elimination. Some dietary phytochemicals are strong inhibito...

Imbalance in oxidant and antioxidant status is one of the commonly observed phenomenon in several pathological conditions including cancer. Also, defect in detoxification cascade leads to accumulation of toxic metabolites, which cause mutation in DNA and leads to neoplastic transformation. Aim of the present study is to focus the chemopreventive potential of Adhatoda vasica leaves during DMBA i...

It has been demonstrated previously that the exposure to 7,12-dimethyl[a]benzanthracene (DMBA) and UVB radiation leads to the development of epidermal cysts, squamous cell carcinomas (SCC), melanocytic hyperplasia and melanoma in human foreskins from newborns grafted to immunodeficient mice. Improved techniques in grafting full-thickness skin from adults have enabled us to study photocarcinogen...

BACKGROUND Recently, several research studies have been focused on the isolation and function of the polysaccharides derived from different algal species, which revealed multiple biological activities such as antioxidant and antitumor activities. This study assesses the possible breast cancer chemopreventive properties of common seaweeds, sea lettuce, Ulva lactuca (ulvan) polysaccharides using ...

Women at increased risk for breast cancer are often also at increased risk for ovarian cancer, reflecting common risk factors and intertwined etiologies for both diseases. Unlike breast cancer prevention, primary ovarian cancer prevention has been impractical due to the low incidence, lack of risk and response biomarkers and difficulties in sampling ovarian tissue. Challenges in the development...

Moringa oleifera Lam. (Moringaceae) is highly valued plant reported to have various biological activities. Considering the antioxidant properties of Moringa oleifera (MO), the chemopreventive property of hydro-ethanolic extract of drumsticks was evaluated on DMBA induced renal carcinogenicity. Groups of 10 male mice were preadministered with MO (200 and 400mg/kg body weight) and standard (0.5%B...

Carnosic acid, a primary phenolic compound found in the leaves of rosemary (Rosmarinus officinalis), has diverse pharmacological and biological activities. The aim of the present study was to investigate the anti-clastogenic effect of carnosic acid in DMBA-induced clastogenesis. The frequency of bone marrow micronucleated polychromatic erythrocytes (MnPCEs), chromosomal aberrations (cytogenetic...

Comparison of the binding to DNA of 7-hydroxymethyl-12-methylbenza(a)anthracene and 7, 12-dimethylbenz(a)anthracene (DMBA) catalyzed by mouse embryo cells in culture or by rat liver microsomes indicates that the products formed are different for the two hydrocarbons. Thus, the hydroxy compound is not an intermediate in the binding of DMBA to DNA in these systems. Binding of the hydroxy compound...