This work reports the synthesis of three multimeric RGD peptidomimetic-paclitaxel conjugates featuring a number of αV β3 integrin ligands ranging from 2 to 4. These constructs were assembled by conjugation of the integrin αV β3 ligand cyclo[DKP-RGD]-CH2 NH2 with paclitaxel via a 2'-carbamate with a self-immolative spacer, the lysosomally cleavable Val-Ala dipeptide linker, a multimeric scaffold...

In this paper, we consider the derivation of the Kadomtsev-Petviashvili (KP) equation for cold ion-acoustic wave in the long wavelength limit of the two-dimensional quantum Euler-Poisson system, under different scalings for varying directions in the Gardner-Morikawa transform. It is shown that the types of the KP equation depend on the scaled quantum parameter H > 0. The QKP-I is derived for H ...

The structures of the diastereomer diketopiperazine dipeptides cyclo(LTyr-LPhe) and cyclo-(DTyr-LPhe) are studied in gas phase using resonance-enhanced two-photon ionization, IR/UV double resonance spectroscopy quantum chemical calculation. Both diastereomers exhibit two conformations, with tyrosine ring folded over DKP phenylalanine extended outwards, or vice versa. differ only slightly by nat...

Mapping and merging of multiple ontologies to produce consistent, coherent and correct merged global ontology is an essential process to enable heterogeneous multi-vendors semantic-based systems to communicate with each other. To generate such a global ontology automatically, the individual ontologies must be free of (all types of) errors. We have observed that the present error classification ...

We study analytically the two dimensional deformed bosonic oscillator equations for charged particles (both spin 0 and 1 particles) subject to effect of a uniform magnetic field. consider presence minimal uncertainty in momentum caused by Anti-deSitter model we use Nikiforov-Uvarov method solve system. The exact energy eigenvalues corresponding wave functions are obtained both Klein-Gordon scal...